Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness
BackgroundAcute high altitude (HA) exposure elicits blood pressure (BP) responses in most subjects, and some of them suffer from acute mountain sickness (AMS). However, a 24-h ambulatory BP (ABP) change and the correlation with the occurrence of AMS in different sexes are still unclear.ObjectivesThi...
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Frontiers Media S.A.
2021-03-01
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Series: | Frontiers in Physiology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.649211/full |
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doaj-69210577e7cc4567804491ecc702bd98 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Renzheng Chen Renzheng Chen Jie Yang Jie Yang Chuan Liu Chuan Liu Mengjia Sun Mengjia Sun Jingbin Ke Jingbin Ke Yuanqi Yang Yuanqi Yang Yang Shen Yang Shen Fangzhengyuan Yuan Fangzhengyuan Yuan Chunyan He Chunyan He Ran Cheng Ran Cheng Hailin Lv Hailin Lv Hu Tan Hu Tan Xubin Gao Xubin Gao Jihang Zhang Jihang Zhang Lan Huang Lan Huang |
spellingShingle |
Renzheng Chen Renzheng Chen Jie Yang Jie Yang Chuan Liu Chuan Liu Mengjia Sun Mengjia Sun Jingbin Ke Jingbin Ke Yuanqi Yang Yuanqi Yang Yang Shen Yang Shen Fangzhengyuan Yuan Fangzhengyuan Yuan Chunyan He Chunyan He Ran Cheng Ran Cheng Hailin Lv Hailin Lv Hu Tan Hu Tan Xubin Gao Xubin Gao Jihang Zhang Jihang Zhang Lan Huang Lan Huang Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness Frontiers in Physiology ambulatory blood pressure sex difference morning blood pressure surge acute mountain sickness headache high altitude |
author_facet |
Renzheng Chen Renzheng Chen Jie Yang Jie Yang Chuan Liu Chuan Liu Mengjia Sun Mengjia Sun Jingbin Ke Jingbin Ke Yuanqi Yang Yuanqi Yang Yang Shen Yang Shen Fangzhengyuan Yuan Fangzhengyuan Yuan Chunyan He Chunyan He Ran Cheng Ran Cheng Hailin Lv Hailin Lv Hu Tan Hu Tan Xubin Gao Xubin Gao Jihang Zhang Jihang Zhang Lan Huang Lan Huang |
author_sort |
Renzheng Chen |
title |
Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness |
title_short |
Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness |
title_full |
Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness |
title_fullStr |
Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness |
title_full_unstemmed |
Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness |
title_sort |
sex-dependent association between early morning ambulatory blood pressure variations and acute mountain sickness |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-03-01 |
description |
BackgroundAcute high altitude (HA) exposure elicits blood pressure (BP) responses in most subjects, and some of them suffer from acute mountain sickness (AMS). However, a 24-h ambulatory BP (ABP) change and the correlation with the occurrence of AMS in different sexes are still unclear.ObjectivesThis prospective study aimed to investigate HA induced BP responses in males and females and the relationship between AMS and 24-h ABP.MethodsForty-six subjects were matched according to demographic parameters by propensity score matching with a ratio of 1:1. All the subjects were monitored by a 24-h ABP device; the measurement was one period of 24 h BP. 2018 Lake Louise questionnaire was used to evaluate AMS.ResultsBoth the incidence of AMS (14 [60.9%] vs. 5 [21.7%], P = 0.007) and headache (18 [78.3%] vs. 8 [34.8%], P = 0.003) were higher in females than in males. All subjects showed an elevated BP in the early morning [morning systolic BP (SBP), 114.72 ± 13.57 vs. 120.67 ± 11.10, P = 0.013]. The elevation of morning SBP variation was more significant in females than in males (11.95 ± 13.19 vs. −0.05 ± 14.49, P = 0.005), and a higher morning BP surge increase (4.69 ± 18.09 vs. −9.66 ± 16.96, P = 0.005) was observed after acute HA exposure in the female group. The increase of morning SBP was associated with AMS occurrence (R = 0.662, P < 0.001) and AMS score (R = 0.664, P = 0.001). Among the AMS symptoms, we further revealed that the incidence (R = 0.786, P < 0.001) and the severity of headache (R = 0.864, P < 0.001) are closely correlated to morning SBP.ConclusionsOur study demonstrates that females are more likely to suffer from AMS than males. AMS is closely associated with elevated BP in the early morning period, which may be correlated to higher headache incidence in subjects with higher morning SBP. |
topic |
ambulatory blood pressure sex difference morning blood pressure surge acute mountain sickness headache high altitude |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2021.649211/full |
work_keys_str_mv |
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doaj-69210577e7cc4567804491ecc702bd982021-03-18T08:08:01ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-03-011210.3389/fphys.2021.649211649211Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain SicknessRenzheng Chen0Renzheng Chen1Jie Yang2Jie Yang3Chuan Liu4Chuan Liu5Mengjia Sun6Mengjia Sun7Jingbin Ke8Jingbin Ke9Yuanqi Yang10Yuanqi Yang11Yang Shen12Yang Shen13Fangzhengyuan Yuan14Fangzhengyuan Yuan15Chunyan He16Chunyan He17Ran Cheng18Ran Cheng19Hailin Lv20Hailin Lv21Hu Tan22Hu Tan23Xubin Gao24Xubin Gao25Jihang Zhang26Jihang Zhang27Lan Huang28Lan Huang29Institute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaInstitute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaBackgroundAcute high altitude (HA) exposure elicits blood pressure (BP) responses in most subjects, and some of them suffer from acute mountain sickness (AMS). However, a 24-h ambulatory BP (ABP) change and the correlation with the occurrence of AMS in different sexes are still unclear.ObjectivesThis prospective study aimed to investigate HA induced BP responses in males and females and the relationship between AMS and 24-h ABP.MethodsForty-six subjects were matched according to demographic parameters by propensity score matching with a ratio of 1:1. All the subjects were monitored by a 24-h ABP device; the measurement was one period of 24 h BP. 2018 Lake Louise questionnaire was used to evaluate AMS.ResultsBoth the incidence of AMS (14 [60.9%] vs. 5 [21.7%], P = 0.007) and headache (18 [78.3%] vs. 8 [34.8%], P = 0.003) were higher in females than in males. All subjects showed an elevated BP in the early morning [morning systolic BP (SBP), 114.72 ± 13.57 vs. 120.67 ± 11.10, P = 0.013]. The elevation of morning SBP variation was more significant in females than in males (11.95 ± 13.19 vs. −0.05 ± 14.49, P = 0.005), and a higher morning BP surge increase (4.69 ± 18.09 vs. −9.66 ± 16.96, P = 0.005) was observed after acute HA exposure in the female group. The increase of morning SBP was associated with AMS occurrence (R = 0.662, P < 0.001) and AMS score (R = 0.664, P = 0.001). Among the AMS symptoms, we further revealed that the incidence (R = 0.786, P < 0.001) and the severity of headache (R = 0.864, P < 0.001) are closely correlated to morning SBP.ConclusionsOur study demonstrates that females are more likely to suffer from AMS than males. AMS is closely associated with elevated BP in the early morning period, which may be correlated to higher headache incidence in subjects with higher morning SBP.https://www.frontiersin.org/articles/10.3389/fphys.2021.649211/fullambulatory blood pressuresex differencemorning blood pressure surgeacute mountain sicknessheadachehigh altitude |