The Lipidome Fingerprint of Longevity

The Lipidome Fingerprint of Longevity

Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal...

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Bibliographic Details
Main Authors: Mariona Jové, Natàlia Mota-Martorell, Irene Pradas, José Daniel Galo-Licona, Meritxell Martín-Gari, Èlia Obis, Joaquim Sol, Reinald Pamplona
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
fatty acids
lipidomics
longevity
membrane unsaturation
peroxidation index
Online Access:https://www.mdpi.com/1420-3049/25/18/4343
Description
Summary:Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species—humans included—demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life.
ISSN:1420-3049

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