Treatment of Human Babesiosis: Then and Now
Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus <i>Babesia</i>. With its increasing incidence worldwide and the risk of human-to-human transmission through blood transfusion, babesiosis is becoming a rising public health concern. The current ars...
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doaj-6937ccd4a29b4af197b2aa436ce797512021-09-26T00:54:17ZengMDPI AGPathogens2076-08172021-09-01101120112010.3390/pathogens10091120Treatment of Human Babesiosis: Then and NowIsaline Renard0Choukri Ben Mamoun1Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT 06520, USADepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT 06520, USABabesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus <i>Babesia</i>. With its increasing incidence worldwide and the risk of human-to-human transmission through blood transfusion, babesiosis is becoming a rising public health concern. The current arsenal for the treatment of human babesiosis is limited and consists of combinations of atovaquone and azithromycin or clindamycin and quinine. These combination therapies were not designed based on biological criteria unique to <i>Babesia</i> parasites, but were rather repurposed based on their well-established efficacy against other apicomplexan parasites. However, these compounds are associated with mild or severe adverse events and a rapid emergence of drug resistance, thus highlighting the need for new therapeutic strategies that are specifically tailored to <i>Babesia</i> parasites. Herein, we review ongoing babesiosis therapeutic and management strategies and their limitations, and further review current efforts to develop new, effective, and safer therapies for the treatment of this disease.https://www.mdpi.com/2076-0817/10/9/1120babesiosis<i>Babesia microti</i><i>Babesia duncani</i>parasitetherapyatovaquone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isaline Renard Choukri Ben Mamoun |
spellingShingle |
Isaline Renard Choukri Ben Mamoun Treatment of Human Babesiosis: Then and Now Pathogens babesiosis <i>Babesia microti</i> <i>Babesia duncani</i> parasite therapy atovaquone |
author_facet |
Isaline Renard Choukri Ben Mamoun |
author_sort |
Isaline Renard |
title |
Treatment of Human Babesiosis: Then and Now |
title_short |
Treatment of Human Babesiosis: Then and Now |
title_full |
Treatment of Human Babesiosis: Then and Now |
title_fullStr |
Treatment of Human Babesiosis: Then and Now |
title_full_unstemmed |
Treatment of Human Babesiosis: Then and Now |
title_sort |
treatment of human babesiosis: then and now |
publisher |
MDPI AG |
series |
Pathogens |
issn |
2076-0817 |
publishDate |
2021-09-01 |
description |
Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus <i>Babesia</i>. With its increasing incidence worldwide and the risk of human-to-human transmission through blood transfusion, babesiosis is becoming a rising public health concern. The current arsenal for the treatment of human babesiosis is limited and consists of combinations of atovaquone and azithromycin or clindamycin and quinine. These combination therapies were not designed based on biological criteria unique to <i>Babesia</i> parasites, but were rather repurposed based on their well-established efficacy against other apicomplexan parasites. However, these compounds are associated with mild or severe adverse events and a rapid emergence of drug resistance, thus highlighting the need for new therapeutic strategies that are specifically tailored to <i>Babesia</i> parasites. Herein, we review ongoing babesiosis therapeutic and management strategies and their limitations, and further review current efforts to develop new, effective, and safer therapies for the treatment of this disease. |
topic |
babesiosis <i>Babesia microti</i> <i>Babesia duncani</i> parasite therapy atovaquone |
url |
https://www.mdpi.com/2076-0817/10/9/1120 |
work_keys_str_mv |
AT isalinerenard treatmentofhumanbabesiosisthenandnow AT choukribenmamoun treatmentofhumanbabesiosisthenandnow |
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