An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis
An ultrasound assisted method has been developed for the Pd-mediated synthesis of indole derivatives in good to acceptable yields. The methodology involved Pd/C-catalyzed coupling–cyclization of 2-iodosulfanilide with alkynes under ultrasound irradiation in the presence of LiCl and NaHCO3 in DMF. A...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-12-01
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Series: | Arabian Journal of Chemistry |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535217300175 |
Summary: | An ultrasound assisted method has been developed for the Pd-mediated synthesis of indole derivatives in good to acceptable yields. The methodology involved Pd/C-catalyzed coupling–cyclization of 2-iodosulfanilide with alkynes under ultrasound irradiation in the presence of LiCl and NaHCO3 in DMF. A variety of internal/terminal alkynes was employed in this CC followed by CN bond forming reaction to afford the corresponding indoles. Being faster and milder method the present ultrasound-based approach appeared to be a useful and cheaper alternative to the existing methods. Keywords: Ultrasound, Pd/C, Indole, Alkyne |
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ISSN: | 1878-5352 |