An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis

An ultrasound assisted method has been developed for the Pd-mediated synthesis of indole derivatives in good to acceptable yields. The methodology involved Pd/C-catalyzed coupling–cyclization of 2-iodosulfanilide with alkynes under ultrasound irradiation in the presence of LiCl and NaHCO3 in DMF. A...

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Main Authors:	Namburi Suresh, Gutta Lakshmi Prasanna, A. Ratnakar, Mandava Venkata Basaveswara Rao, Manojit Pal
Format:	Article
Language:	English
Published:	Elsevier 2019-12-01
Series:	Arabian Journal of Chemistry
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535217300175

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spelling	doaj-6942eeb81a0f407893feb3f5c3c6a0782020-11-25T02:44:56ZengElsevierArabian Journal of Chemistry1878-53522019-12-0112853705379An ultrasound-based approach for the synthesis of indoles under Pd/C catalysisNamburi Suresh0Gutta Lakshmi Prasanna1A. Ratnakar2Mandava Venkata Basaveswara Rao3Manojit Pal4Department of Chemistry, Krishna University, Krishna District, Andhra Pradesh, IndiaDepartment of Chemistry, Krishna University, Krishna District, Andhra Pradesh, IndiaDepartment of Chemistry, V. R. Siddhartha College of Engineering, Vijayawada, Andhra Pradesh, IndiaDepartment of Chemistry, Krishna University, Krishna District, Andhra Pradesh, India; Corresponding authors.Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India; Corresponding authors.An ultrasound assisted method has been developed for the Pd-mediated synthesis of indole derivatives in good to acceptable yields. The methodology involved Pd/C-catalyzed coupling–cyclization of 2-iodosulfanilide with alkynes under ultrasound irradiation in the presence of LiCl and NaHCO3 in DMF. A variety of internal/terminal alkynes was employed in this CC followed by CN bond forming reaction to afford the corresponding indoles. Being faster and milder method the present ultrasound-based approach appeared to be a useful and cheaper alternative to the existing methods. Keywords: Ultrasound, Pd/C, Indole, Alkynehttp://www.sciencedirect.com/science/article/pii/S1878535217300175
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Namburi Suresh Gutta Lakshmi Prasanna A. Ratnakar Mandava Venkata Basaveswara Rao Manojit Pal
spellingShingle	Namburi Suresh Gutta Lakshmi Prasanna A. Ratnakar Mandava Venkata Basaveswara Rao Manojit Pal An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis Arabian Journal of Chemistry
author_facet	Namburi Suresh Gutta Lakshmi Prasanna A. Ratnakar Mandava Venkata Basaveswara Rao Manojit Pal
author_sort	Namburi Suresh
title	An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis
title_short	An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis
title_full	An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis
title_fullStr	An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis
title_full_unstemmed	An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis
title_sort	ultrasound-based approach for the synthesis of indoles under pd/c catalysis
publisher	Elsevier
series	Arabian Journal of Chemistry
issn	1878-5352
publishDate	2019-12-01
description	An ultrasound assisted method has been developed for the Pd-mediated synthesis of indole derivatives in good to acceptable yields. The methodology involved Pd/C-catalyzed coupling–cyclization of 2-iodosulfanilide with alkynes under ultrasound irradiation in the presence of LiCl and NaHCO3 in DMF. A variety of internal/terminal alkynes was employed in this CC followed by CN bond forming reaction to afford the corresponding indoles. Being faster and milder method the present ultrasound-based approach appeared to be a useful and cheaper alternative to the existing methods. Keywords: Ultrasound, Pd/C, Indole, Alkyne
url	http://www.sciencedirect.com/science/article/pii/S1878535217300175
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An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis

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