An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis
An ultrasound assisted method has been developed for the Pd-mediated synthesis of indole derivatives in good to acceptable yields. The methodology involved Pd/C-catalyzed coupling–cyclization of 2-iodosulfanilide with alkynes under ultrasound irradiation in the presence of LiCl and NaHCO3 in DMF. A...
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2019-12-01
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Series: | Arabian Journal of Chemistry |
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doaj-6942eeb81a0f407893feb3f5c3c6a0782020-11-25T02:44:56ZengElsevierArabian Journal of Chemistry1878-53522019-12-0112853705379An ultrasound-based approach for the synthesis of indoles under Pd/C catalysisNamburi Suresh0Gutta Lakshmi Prasanna1A. Ratnakar2Mandava Venkata Basaveswara Rao3Manojit Pal4Department of Chemistry, Krishna University, Krishna District, Andhra Pradesh, IndiaDepartment of Chemistry, Krishna University, Krishna District, Andhra Pradesh, IndiaDepartment of Chemistry, V. R. Siddhartha College of Engineering, Vijayawada, Andhra Pradesh, IndiaDepartment of Chemistry, Krishna University, Krishna District, Andhra Pradesh, India; Corresponding authors.Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India; Corresponding authors.An ultrasound assisted method has been developed for the Pd-mediated synthesis of indole derivatives in good to acceptable yields. The methodology involved Pd/C-catalyzed coupling–cyclization of 2-iodosulfanilide with alkynes under ultrasound irradiation in the presence of LiCl and NaHCO3 in DMF. A variety of internal/terminal alkynes was employed in this CC followed by CN bond forming reaction to afford the corresponding indoles. Being faster and milder method the present ultrasound-based approach appeared to be a useful and cheaper alternative to the existing methods. Keywords: Ultrasound, Pd/C, Indole, Alkynehttp://www.sciencedirect.com/science/article/pii/S1878535217300175 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Namburi Suresh Gutta Lakshmi Prasanna A. Ratnakar Mandava Venkata Basaveswara Rao Manojit Pal |
spellingShingle |
Namburi Suresh Gutta Lakshmi Prasanna A. Ratnakar Mandava Venkata Basaveswara Rao Manojit Pal An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis Arabian Journal of Chemistry |
author_facet |
Namburi Suresh Gutta Lakshmi Prasanna A. Ratnakar Mandava Venkata Basaveswara Rao Manojit Pal |
author_sort |
Namburi Suresh |
title |
An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis |
title_short |
An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis |
title_full |
An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis |
title_fullStr |
An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis |
title_full_unstemmed |
An ultrasound-based approach for the synthesis of indoles under Pd/C catalysis |
title_sort |
ultrasound-based approach for the synthesis of indoles under pd/c catalysis |
publisher |
Elsevier |
series |
Arabian Journal of Chemistry |
issn |
1878-5352 |
publishDate |
2019-12-01 |
description |
An ultrasound assisted method has been developed for the Pd-mediated synthesis of indole derivatives in good to acceptable yields. The methodology involved Pd/C-catalyzed coupling–cyclization of 2-iodosulfanilide with alkynes under ultrasound irradiation in the presence of LiCl and NaHCO3 in DMF. A variety of internal/terminal alkynes was employed in this CC followed by CN bond forming reaction to afford the corresponding indoles. Being faster and milder method the present ultrasound-based approach appeared to be a useful and cheaper alternative to the existing methods. Keywords: Ultrasound, Pd/C, Indole, Alkyne |
url |
http://www.sciencedirect.com/science/article/pii/S1878535217300175 |
work_keys_str_mv |
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