Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months
Introduction. Microfragmented adipose tissue (MFAT) has been shown to benefit osteoarthritic patients by reducing pain and supporting tissue regeneration through a mesenchymal stem cell (MSC)-related paracrine mechanism. This observational study of 110 knees assessed patient-centered outcomes of pai...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2020-01-01
|
Series: | Stem Cells International |
Online Access: | http://dx.doi.org/10.1155/2020/8881405 |
id |
doaj-69433c925eff49a6bc39640f039b5812 |
---|---|
record_format |
Article |
spelling |
doaj-69433c925eff49a6bc39640f039b58122020-11-25T03:36:03ZengHindawi LimitedStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88814058881405Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve MonthsNima Heidari0Ali Noorani1Mark Slevin2Angela Cullen3Laura Stark4Stefano Olgiati5Alberto Zerbi6Adrian Wilson7The Regenerative Clinic, 18-22 Queen Anne Street, London, UKThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKDepartment of Life Sciences, Manchester Metropolitan University, UKThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKDept. of Morphology, Surgery and Experimental Medicine, Faculty of Medicine, University of Ferrara, 44121 Ferrara, ItalyUniversity of Milano, Dept. of Radiology, 20100 Milano, ItalyThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKIntroduction. Microfragmented adipose tissue (MFAT) has been shown to benefit osteoarthritic patients by reducing pain and supporting tissue regeneration through a mesenchymal stem cell (MSC)-related paracrine mechanism. This observational study of 110 knees assessed patient-centered outcomes of pain, functionality, and quality of life, analyzing their variation at twelve months following one ultrasound-guided intra-articular injection of autologous MFAT for the treatment of knee osteoarthritis (KOA). Method. Inclusion criteria were as follows: VAS >50, and the presence of KOA as diagnosed on X-ray and MRI. Exclusion criteria included the following: recent injury (<3 months) of the symptomatic knee, intra-articular steroid injections performed within the last three months, and hyaluronic acid injections prior to this treatment. Changes in VAS, OKS, and EQ-5D were scored at baseline and twelve months following a single intra-articular injection of autologous MFAT. Score variation was analyzed utilizing a nonparametric paired samples Wilcoxon test. The statistical analysis is reproducible with Open Access statistical software R (version 4.0.0 or higher). The study was carried out with full patient consent, in a private practice setting. Results. Median VAS (pain) improved from 70 (IQR 20) to 30 (IQR 58) (p<0.001); median OKS (function) improved from 25 (IQR 11) to 33.5 (IQR 16) (p<0.001); and median EQ-5D (quality of life) improved from 0.62 (IQR 0.41) to 0.69 (IQR 0.28) (p<0.001). No adverse events were reported during the intraoperative, recovery, or postoperative periods. Conclusions. For patients with all grades of knee osteoarthritis who were treated with intra-articular injections of MFAT, statistically significant improvements in pain, function, and quality of life were reported. Although further research is warranted, the results are encouraging and suggest a positive role for intra-articular injection of MFAT as a treatment for knee osteoarthritis.http://dx.doi.org/10.1155/2020/8881405 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nima Heidari Ali Noorani Mark Slevin Angela Cullen Laura Stark Stefano Olgiati Alberto Zerbi Adrian Wilson |
spellingShingle |
Nima Heidari Ali Noorani Mark Slevin Angela Cullen Laura Stark Stefano Olgiati Alberto Zerbi Adrian Wilson Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months Stem Cells International |
author_facet |
Nima Heidari Ali Noorani Mark Slevin Angela Cullen Laura Stark Stefano Olgiati Alberto Zerbi Adrian Wilson |
author_sort |
Nima Heidari |
title |
Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months |
title_short |
Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months |
title_full |
Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months |
title_fullStr |
Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months |
title_full_unstemmed |
Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months |
title_sort |
patient-centered outcomes of microfragmented adipose tissue treatments of knee osteoarthritis: an observational, intention-to-treat study at twelve months |
publisher |
Hindawi Limited |
series |
Stem Cells International |
issn |
1687-966X 1687-9678 |
publishDate |
2020-01-01 |
description |
Introduction. Microfragmented adipose tissue (MFAT) has been shown to benefit osteoarthritic patients by reducing pain and supporting tissue regeneration through a mesenchymal stem cell (MSC)-related paracrine mechanism. This observational study of 110 knees assessed patient-centered outcomes of pain, functionality, and quality of life, analyzing their variation at twelve months following one ultrasound-guided intra-articular injection of autologous MFAT for the treatment of knee osteoarthritis (KOA). Method. Inclusion criteria were as follows: VAS >50, and the presence of KOA as diagnosed on X-ray and MRI. Exclusion criteria included the following: recent injury (<3 months) of the symptomatic knee, intra-articular steroid injections performed within the last three months, and hyaluronic acid injections prior to this treatment. Changes in VAS, OKS, and EQ-5D were scored at baseline and twelve months following a single intra-articular injection of autologous MFAT. Score variation was analyzed utilizing a nonparametric paired samples Wilcoxon test. The statistical analysis is reproducible with Open Access statistical software R (version 4.0.0 or higher). The study was carried out with full patient consent, in a private practice setting. Results. Median VAS (pain) improved from 70 (IQR 20) to 30 (IQR 58) (p<0.001); median OKS (function) improved from 25 (IQR 11) to 33.5 (IQR 16) (p<0.001); and median EQ-5D (quality of life) improved from 0.62 (IQR 0.41) to 0.69 (IQR 0.28) (p<0.001). No adverse events were reported during the intraoperative, recovery, or postoperative periods. Conclusions. For patients with all grades of knee osteoarthritis who were treated with intra-articular injections of MFAT, statistically significant improvements in pain, function, and quality of life were reported. Although further research is warranted, the results are encouraging and suggest a positive role for intra-articular injection of MFAT as a treatment for knee osteoarthritis. |
url |
http://dx.doi.org/10.1155/2020/8881405 |
work_keys_str_mv |
AT nimaheidari patientcenteredoutcomesofmicrofragmentedadiposetissuetreatmentsofkneeosteoarthritisanobservationalintentiontotreatstudyattwelvemonths AT alinoorani patientcenteredoutcomesofmicrofragmentedadiposetissuetreatmentsofkneeosteoarthritisanobservationalintentiontotreatstudyattwelvemonths AT markslevin patientcenteredoutcomesofmicrofragmentedadiposetissuetreatmentsofkneeosteoarthritisanobservationalintentiontotreatstudyattwelvemonths AT angelacullen patientcenteredoutcomesofmicrofragmentedadiposetissuetreatmentsofkneeosteoarthritisanobservationalintentiontotreatstudyattwelvemonths AT laurastark patientcenteredoutcomesofmicrofragmentedadiposetissuetreatmentsofkneeosteoarthritisanobservationalintentiontotreatstudyattwelvemonths AT stefanoolgiati patientcenteredoutcomesofmicrofragmentedadiposetissuetreatmentsofkneeosteoarthritisanobservationalintentiontotreatstudyattwelvemonths AT albertozerbi patientcenteredoutcomesofmicrofragmentedadiposetissuetreatmentsofkneeosteoarthritisanobservationalintentiontotreatstudyattwelvemonths AT adrianwilson patientcenteredoutcomesofmicrofragmentedadiposetissuetreatmentsofkneeosteoarthritisanobservationalintentiontotreatstudyattwelvemonths |
_version_ |
1715168553201565696 |