PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

The peroxisome proliferator-activated receptor δ (PPARδ) is implicated in regulation of mitochondrial processes in a number of tissues, and PPARδ activation is associated with decreased susceptibility to ectopic lipid deposition and metabolic disease. Here, we show that PPARδ is the PPAR subtype exp...

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Bibliographic Details
Main Authors: Kim Ravnskjaer, Francesca Frigerio, Michael Boergesen, Tina Nielsen, Pierre Maechler, Susanne Mandrup
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Journal of Lipid Research
Subjects:
peroxisome proliferator-activated receptor δ
β-cells
β-oxidation
fatty acids
glucose-stimulated insulin secretion
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410119

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