Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature
Abstract Large bone defects resulting from musculoskeletal tumours, infections, or trauma are often unable to heal spontaneously. The challenge for surgeons is to avoid amputation, and provide the best functional outcomes. Allograft, vascularized fibular or iliac graft, hybrid graft, extracorporeal...
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doaj-694e6f589c6948a99a7271ff3d0705db2021-10-03T11:39:29ZengBMCEuropean Journal of Medical Research2047-783X2021-10-0126111010.1186/s40001-021-00593-9Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literatureFilippo Migliorini0Gerardo La Padula1Ernesto Torsiello2Filippo Spiezia3Francesco Oliva4Nicola Maffulli5Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University HospitalDepartment of Medicine, Surgery and Dentistry, University of SalernoDepartment of Medicine, Surgery and Dentistry, University of SalernoOspedale San Carlo PotenzaDepartment of Medicine, Surgery and Dentistry, University of SalernoDepartment of Medicine, Surgery and Dentistry, University of SalernoAbstract Large bone defects resulting from musculoskeletal tumours, infections, or trauma are often unable to heal spontaneously. The challenge for surgeons is to avoid amputation, and provide the best functional outcomes. Allograft, vascularized fibular or iliac graft, hybrid graft, extracorporeal devitalized autograft, distraction osteogenesis, induced-membrane technique, and segmental prostheses are the most common surgical strategies to manage large bone defects. Given its optimal osteogenesis, osteoinduction, osteoconduction, and histocompatibility properties, along with the lower the risk of immunological rejection, autologous graft represents the most common used strategy for reconstruction of bone defects. However, the choice of the best surgical technique is still debated, and no consensus has been reached. The present study investigated the current reconstructive strategies for large bone defect after trauma, infections, or tumour excision, discussed advantages and disadvantages of each technique, debated available techniques and materials, and evaluated complications and new perspectives.https://doi.org/10.1186/s40001-021-00593-9Bone defectBiologicalAutologousGraft |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Filippo Migliorini Gerardo La Padula Ernesto Torsiello Filippo Spiezia Francesco Oliva Nicola Maffulli |
spellingShingle |
Filippo Migliorini Gerardo La Padula Ernesto Torsiello Filippo Spiezia Francesco Oliva Nicola Maffulli Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature European Journal of Medical Research Bone defect Biological Autologous Graft |
author_facet |
Filippo Migliorini Gerardo La Padula Ernesto Torsiello Filippo Spiezia Francesco Oliva Nicola Maffulli |
author_sort |
Filippo Migliorini |
title |
Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature |
title_short |
Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature |
title_full |
Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature |
title_fullStr |
Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature |
title_full_unstemmed |
Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature |
title_sort |
strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature |
publisher |
BMC |
series |
European Journal of Medical Research |
issn |
2047-783X |
publishDate |
2021-10-01 |
description |
Abstract Large bone defects resulting from musculoskeletal tumours, infections, or trauma are often unable to heal spontaneously. The challenge for surgeons is to avoid amputation, and provide the best functional outcomes. Allograft, vascularized fibular or iliac graft, hybrid graft, extracorporeal devitalized autograft, distraction osteogenesis, induced-membrane technique, and segmental prostheses are the most common surgical strategies to manage large bone defects. Given its optimal osteogenesis, osteoinduction, osteoconduction, and histocompatibility properties, along with the lower the risk of immunological rejection, autologous graft represents the most common used strategy for reconstruction of bone defects. However, the choice of the best surgical technique is still debated, and no consensus has been reached. The present study investigated the current reconstructive strategies for large bone defect after trauma, infections, or tumour excision, discussed advantages and disadvantages of each technique, debated available techniques and materials, and evaluated complications and new perspectives. |
topic |
Bone defect Biological Autologous Graft |
url |
https://doi.org/10.1186/s40001-021-00593-9 |
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