Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.

Bibliographic Details
Main Authors: J. L. Imbach, J. L. Barascut, H. B. Lazrek, M. Taourirte, A. Rochdi
Format: Article
Language:English
Published: MDPI AG 2000-10-01
Series:Molecules
Subjects:
Acyclonucleoside
Phophonoalkenyl
Michael addition
N-3-alkylation
Online Access:http://www.mdpi.com/1420-3049/5/10/1139/
Description
Summary:The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.
ISSN:1420-3049

Similar Items