Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate
The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2000-10-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/5/10/1139/ |
| id |
doaj-694eee5d484f403bb95cfcd81bb8627e |
|---|---|
| record_format |
Article |
| spelling |
doaj-694eee5d484f403bb95cfcd81bb8627e2020-11-24T20:41:34ZengMDPI AGMolecules1420-30492000-10-015101139114510.3390/51001139Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl PhosphonateJ. L. ImbachJ. L. BarascutH. B. LazrekM. TaourirteA. RochdiThe E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.http://www.mdpi.com/1420-3049/5/10/1139/AcyclonucleosidePhophonoalkenylMichael additionN-3-alkylation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
J. L. Imbach J. L. Barascut H. B. Lazrek M. Taourirte A. Rochdi |
| spellingShingle |
J. L. Imbach J. L. Barascut H. B. Lazrek M. Taourirte A. Rochdi Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate Molecules Acyclonucleoside Phophonoalkenyl Michael addition N-3-alkylation |
| author_facet |
J. L. Imbach J. L. Barascut H. B. Lazrek M. Taourirte A. Rochdi |
| author_sort |
J. L. Imbach |
| title |
Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate |
| title_short |
Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate |
| title_full |
Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate |
| title_fullStr |
Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate |
| title_full_unstemmed |
Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate |
| title_sort |
synthesis of new bis-alkylated phosphono alkenyl acyclonucleosides : (z) and (e)-diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl phosphonate |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2000-10-01 |
| description |
The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF. |
| topic |
Acyclonucleoside Phophonoalkenyl Michael addition N-3-alkylation |
| url |
http://www.mdpi.com/1420-3049/5/10/1139/ |
| work_keys_str_mv |
AT jlimbach synthesisofnewbisalkylatedphosphonoalkenylacyclonucleosideszandediethyl23alkylpyrimidin1ylethylen1ylphosphonate AT jlbarascut synthesisofnewbisalkylatedphosphonoalkenylacyclonucleosideszandediethyl23alkylpyrimidin1ylethylen1ylphosphonate AT hblazrek synthesisofnewbisalkylatedphosphonoalkenylacyclonucleosideszandediethyl23alkylpyrimidin1ylethylen1ylphosphonate AT mtaourirte synthesisofnewbisalkylatedphosphonoalkenylacyclonucleosideszandediethyl23alkylpyrimidin1ylethylen1ylphosphonate AT arochdi synthesisofnewbisalkylatedphosphonoalkenylacyclonucleosideszandediethyl23alkylpyrimidin1ylethylen1ylphosphonate |
| _version_ |
1716824614610403328 |