TET proteins and epigenetic modifications in cancers
Epigenetic modifications, including DNA methylation and histone modifications, are involved in regulation of gene expression, and alterations in these modifications are implicated in cancer onset and progression. The specific pattern of DNA methylation depends on the balance between methylation and...
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2015-12-01
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doaj-694f07c6591445ca8ca9e2488bca153a2020-11-24T23:08:58ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932015-12-01691371138310.5604/01.3001.0009.660801.3001.0009.6608TET proteins and epigenetic modifications in cancersPiotr Ciesielski0Paweł Jóźwiak1Anna Krześlak2Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska, Katedra Cytobiochemii, ŁódźUniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska, Katedra Cytobiochemii, ŁódźUniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska, Katedra Cytobiochemii, ŁódźEpigenetic modifications, including DNA methylation and histone modifications, are involved in regulation of gene expression, and alterations in these modifications are implicated in cancer onset and progression. The specific pattern of DNA methylation depends on the balance between methylation and demethylation processes. Recent studies have shown that TET proteins play a key role in DNA demethylation. TET proteins (TET1, TET2, TET3) are iron(II) and α-ketoglutarate dependent dioxygenases, and their enzymatic activity involves hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine and further to 5-formylcytosine and 5-carboxylcytosine. These modified cytosines are removed by enzymes involved in DNA repair. However, the role of TETs in gene expression regulation is not limited to their catalytic activity. TETs can interact with proteins of complexes involved in the modification of histones (i.e. EZH2, OGT, Sin3a or HCF1) and by affecting their activity and, chromatin binding ability, they can cause changes in patterns of histone methylation, acetylation and O-GlcNAcylation. There is growing evidence that decreased expression of TET proteins and mutation in TET genes are associated with cancer onset and progression. http://phmd.pl/gicid/01.3001.0009.66085-hydroksymetylocytozynabiałka TETdemetylacja DNAmodyfikacje epigenetycznesupresory nowotworów5-hydroxymethylcytosine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Piotr Ciesielski Paweł Jóźwiak Anna Krześlak |
spellingShingle |
Piotr Ciesielski Paweł Jóźwiak Anna Krześlak TET proteins and epigenetic modifications in cancers Postępy Higieny i Medycyny Doświadczalnej 5-hydroksymetylocytozyna białka TET demetylacja DNA modyfikacje epigenetyczne supresory nowotworów 5-hydroxymethylcytosine |
author_facet |
Piotr Ciesielski Paweł Jóźwiak Anna Krześlak |
author_sort |
Piotr Ciesielski |
title |
TET proteins and epigenetic modifications in cancers |
title_short |
TET proteins and epigenetic modifications in cancers |
title_full |
TET proteins and epigenetic modifications in cancers |
title_fullStr |
TET proteins and epigenetic modifications in cancers |
title_full_unstemmed |
TET proteins and epigenetic modifications in cancers |
title_sort |
tet proteins and epigenetic modifications in cancers |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2015-12-01 |
description |
Epigenetic modifications, including DNA methylation and histone modifications, are involved in regulation of gene expression, and alterations in these modifications are implicated in cancer onset and progression. The specific pattern of DNA methylation depends on the balance between methylation and demethylation processes. Recent studies have shown that TET proteins play a key role in DNA demethylation. TET proteins (TET1, TET2, TET3) are iron(II) and α-ketoglutarate dependent dioxygenases, and their enzymatic activity involves hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine and further to 5-formylcytosine and 5-carboxylcytosine. These modified cytosines are removed by enzymes involved in DNA repair. However, the role of TETs in gene expression regulation is not limited to their catalytic activity. TETs can interact with proteins of complexes involved in the modification of histones (i.e. EZH2, OGT, Sin3a or HCF1) and by affecting their activity and, chromatin binding ability, they can cause changes in patterns of histone methylation, acetylation and O-GlcNAcylation. There is growing evidence that decreased expression of TET proteins and mutation in TET genes are associated with cancer onset and progression.
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topic |
5-hydroksymetylocytozyna białka TET demetylacja DNA modyfikacje epigenetyczne supresory nowotworów 5-hydroxymethylcytosine |
url |
http://phmd.pl/gicid/01.3001.0009.6608 |
work_keys_str_mv |
AT piotrciesielski tetproteinsandepigeneticmodificationsincancers AT pawełjozwiak tetproteinsandepigeneticmodificationsincancers AT annakrzeslak tetproteinsandepigeneticmodificationsincancers |
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1725612086653878272 |