Shikonin Ameliorates LPS-Induced Cardiac Dysfunction by SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Shikonin Ameliorates LPS-Induced Cardiac Dysfunction by SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Shikonin (SHI) is an anti-inflammatory agent extracted from natural herbs. It is still unknown whether SHI ameliorates lipopolysaccharide (LPS)-induced cardiac dysfunction. This study aims to explore the protective effects of SHI on LPS-induced myocardial injury and its mechanism. The LPS-induced ca...

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Bibliographic Details
Main Authors: Tao Guo, Zhong-Biao Jiang, Zhong-Yi Tong, Yang Zhou, Xiang-Ping Chai, Xian-Zhong Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
shikonin
lipopolysaccharide
SIRT1
NLRP3
cardiac dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.570441/full

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