A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid

A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid

Bullous pemphigoid (BP) is an autoimmune bullous disease and is a rare condition in childhood. Acquired tense acral bullae and fixed urticarial annular lesions on the trunk are diagnostic clues of infantile BP. Diagnosis is supported by immunosorbent assay (IgG anti-BP180 and BP230) and direct immun...

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Bibliographic Details
Main Authors: Iria Neri, Valeria Evangelista, Alba Guglielmo, Andrea Sechi, Annalucia Virdi
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Dermatopathology
Subjects:
autoimmune bullous rash
bullous pemphigoid
infants
vaccine
Online Access:https://www.mdpi.com/2296-3529/8/1/6
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spelling doaj-695dad7a13464ef2a9db28d915d47e0f2021-02-24T00:02:30ZengMDPI AGDermatopathology2296-35292021-02-0186333610.3390/dermatopathology8010006A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous PemphigoidIria Neri0Valeria Evangelista1Alba Guglielmo2Andrea Sechi3Annalucia Virdi4Dermatology—IRCCS Policlinico di Sant’Orsola—Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, 40138 Bologna, ItalyDermatology—IRCCS Policlinico di Sant’Orsola—Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, 40138 Bologna, ItalyDermatology—IRCCS Policlinico di Sant’Orsola—Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, 40138 Bologna, ItalyDermatology—IRCCS Policlinico di Sant’Orsola—Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, 40138 Bologna, ItalyDermatology—IRCCS Policlinico di Sant’Orsola—Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, 40138 Bologna, ItalyBullous pemphigoid (BP) is an autoimmune bullous disease and is a rare condition in childhood. Acquired tense acral bullae and fixed urticarial annular lesions on the trunk are diagnostic clues of infantile BP. Diagnosis is supported by immunosorbent assay (IgG anti-BP180 and BP230) and direct immunofluorescence (linear deposition of IgG at the dermo-epidermal junction). Topical and/or systemic corticosteroids are the first-line treatment. The prognosis is good with a self-limited clinical course. Differential diagnoses include impetigo and other bullous diseases in children, such as dermatitis herpetiformis, linear IgA bullous dermatosis and erythema multiforme. The etiopathogenesis is still unknown, and the role of antigen stimuli such as infections, drugs and vaccination is still debated.https://www.mdpi.com/2296-3529/8/1/6autoimmune bullous rashbullous pemphigoidinfantsvaccine
collection DOAJ
language English
format Article
sources DOAJ
author Iria Neri
Valeria Evangelista
Alba Guglielmo
Andrea Sechi
Annalucia Virdi
spellingShingle Iria Neri
Valeria Evangelista
Alba Guglielmo
Andrea Sechi
Annalucia Virdi
A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid
Dermatopathology
autoimmune bullous rash
bullous pemphigoid
infants
vaccine
author_facet Iria Neri
Valeria Evangelista
Alba Guglielmo
Andrea Sechi
Annalucia Virdi
author_sort Iria Neri
title A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid
title_short A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid
title_full A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid
title_fullStr A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid
title_full_unstemmed A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid
title_sort case of bullous rash apparently triggered by meningococcal and rotavirus vaccines in an infant: focus on infantile bullous pemphigoid
publisher MDPI AG
series Dermatopathology
issn 2296-3529
publishDate 2021-02-01
description Bullous pemphigoid (BP) is an autoimmune bullous disease and is a rare condition in childhood. Acquired tense acral bullae and fixed urticarial annular lesions on the trunk are diagnostic clues of infantile BP. Diagnosis is supported by immunosorbent assay (IgG anti-BP180 and BP230) and direct immunofluorescence (linear deposition of IgG at the dermo-epidermal junction). Topical and/or systemic corticosteroids are the first-line treatment. The prognosis is good with a self-limited clinical course. Differential diagnoses include impetigo and other bullous diseases in children, such as dermatitis herpetiformis, linear IgA bullous dermatosis and erythema multiforme. The etiopathogenesis is still unknown, and the role of antigen stimuli such as infections, drugs and vaccination is still debated.
topic autoimmune bullous rash
bullous pemphigoid
infants
vaccine
url https://www.mdpi.com/2296-3529/8/1/6
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