relA Inactivation Converts Sulfonamides Into Bactericidal Compounds
Folates are required for the de novo biosynthesis of purines, thymine, methionine, glycine, and pantothenic acid, key metabolites that bacterial cells cannot survive without. Sulfonamides, which inhibit bacterial folate biosynthesis and are generally considered as bacteriostats, have been extensivel...
Main Authors: | Lizhen Si, Jing Gu, Mi Wen, Ruiqi Wang, Joy Fleming, Jinyue Li, Jintian Xu, Lijun Bi, Jiaoyu Deng |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-09-01
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Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.698468/full |
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