Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress
Periodontitis is a type of systemic immune inflammation that is caused by the complex infection of a variety of microorganisms in the subgingival plaque and the imbalance of the microbial ecological environment in the mouth. Periodontitis and chronic kidney disease (CKD) share many risk factors, suc...
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doaj-697c210c13974a7fb5a1e8501c4a9f002021-06-14T15:02:37ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-06-011210.3389/fmicb.2021.656372656372Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative StressLing Li0Ya-Li Zhang1Xing-Yu Liu2Xiang Meng3Rong-Quan Zhao4Lin-Lin Ou5Bao-Zhu Li6Tian Xing7Tian Xing8School of Stomatology, Anhui Medical University, Hefei, ChinaSchool of Stomatology, Anhui Medical University, Hefei, ChinaSchool of Stomatology, Anhui Medical University, Hefei, ChinaKey Laboratory of Oral Diseases Research of Anhui Province, College and Hospital of Stomatology, Anhui Medical University, Hefei, ChinaSchool of Stomatology, Anhui Medical University, Hefei, ChinaSchool of Stomatology, Anhui Medical University, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaSchool of Stomatology, Anhui Medical University, Hefei, ChinaKey Laboratory of Oral Diseases Research of Anhui Province, College and Hospital of Stomatology, Anhui Medical University, Hefei, ChinaPeriodontitis is a type of systemic immune inflammation that is caused by the complex infection of a variety of microorganisms in the subgingival plaque and the imbalance of the microbial ecological environment in the mouth. Periodontitis and chronic kidney disease (CKD) share many risk factors, such as obesity, smoking, and age. A growing body of data supports a strong correlation between periodontitis and kidney disease. Evidence supports the role of periodontal inflammation and elevated serum inflammatory mediators in renal atherosclerosis, renal deterioration, and end-stage renal disease (ESRD) development. Periodontitis is a risk factor for kidney disease. However, to our knowledge, there are few studies detailing the possible link between periodontitis and CKD. This review summarizes the possible mechanisms underlying periodontitis and CKD. More importantly, it highlights novel and potential pathogenic factors for CKD, including bacteria, pro-inflammatory mediators and oxidative stress. However, most research on the relationship between periodontitis and systemic disease has not determined causality, and these diseases are largely linked by bidirectional associations. Future research will focus on exploring these links to contribute to new treatments for CKD.https://www.frontiersin.org/articles/10.3389/fmicb.2021.656372/fullchronic kidney diseaseoral floraoxidative stressperiodontitisproinflammatory mediators |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ling Li Ya-Li Zhang Xing-Yu Liu Xiang Meng Rong-Quan Zhao Lin-Lin Ou Bao-Zhu Li Tian Xing Tian Xing |
spellingShingle |
Ling Li Ya-Li Zhang Xing-Yu Liu Xiang Meng Rong-Quan Zhao Lin-Lin Ou Bao-Zhu Li Tian Xing Tian Xing Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress Frontiers in Microbiology chronic kidney disease oral flora oxidative stress periodontitis proinflammatory mediators |
author_facet |
Ling Li Ya-Li Zhang Xing-Yu Liu Xiang Meng Rong-Quan Zhao Lin-Lin Ou Bao-Zhu Li Tian Xing Tian Xing |
author_sort |
Ling Li |
title |
Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress |
title_short |
Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress |
title_full |
Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress |
title_fullStr |
Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress |
title_full_unstemmed |
Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress |
title_sort |
periodontitis exacerbates and promotes the progression of chronic kidney disease through oral flora, cytokines, and oxidative stress |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2021-06-01 |
description |
Periodontitis is a type of systemic immune inflammation that is caused by the complex infection of a variety of microorganisms in the subgingival plaque and the imbalance of the microbial ecological environment in the mouth. Periodontitis and chronic kidney disease (CKD) share many risk factors, such as obesity, smoking, and age. A growing body of data supports a strong correlation between periodontitis and kidney disease. Evidence supports the role of periodontal inflammation and elevated serum inflammatory mediators in renal atherosclerosis, renal deterioration, and end-stage renal disease (ESRD) development. Periodontitis is a risk factor for kidney disease. However, to our knowledge, there are few studies detailing the possible link between periodontitis and CKD. This review summarizes the possible mechanisms underlying periodontitis and CKD. More importantly, it highlights novel and potential pathogenic factors for CKD, including bacteria, pro-inflammatory mediators and oxidative stress. However, most research on the relationship between periodontitis and systemic disease has not determined causality, and these diseases are largely linked by bidirectional associations. Future research will focus on exploring these links to contribute to new treatments for CKD. |
topic |
chronic kidney disease oral flora oxidative stress periodontitis proinflammatory mediators |
url |
https://www.frontiersin.org/articles/10.3389/fmicb.2021.656372/full |
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