Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection
Gastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in Mexico. Causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. Recent molecular studies have transgressed a number of genes involved...
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doaj-697e0234f7334c13a37bc78d999437382020-11-24T21:11:23ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2017-05-01410.3389/fmed.2017.00047256545Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori InfectionGonzalo Castillo-Rojas0Claudia I. Rivas-Ortiz1Yolanda Lopez-Vidal2Luis Jose Rene Arredondo-Hernandez3Programa de Inmunología Molecular Microbiana, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, MexicoPrograma de Inmunología Molecular Microbiana, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, MexicoPrograma de Inmunología Molecular Microbiana, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, MexicoPrograma de Microbioma, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, MexicoGastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in Mexico. Causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. Recent molecular studies have transgressed a number of genes involved in gastric carcinogenesis. The aim of this review is to understand the recent basics of gene expression in the development of the process of gastric carcinogenesis. Genetic variants, polymorphisms, desoxyribonucleic acid methylation, and genes involved in mediating inflammation have been associated with the development of gastric carcinogenesis. Recently, these genes (interleukin 10, Il-17, mucin 1, β-catenin, CDX1, SMAD4, SERPINE1, hypoxia-inducible factor 1 subunit alpha, GSK3β, CDH17, matrix metalloproteinase 7, RUNX3, RASSF1A, TFF1, HAI-2, and COX-2) have been studied in association with oncogenic activation or inactivation of tumor suppressor genes. All these mechanisms have been investigated to elucidate the process of gastric carcinogenesis, as well as their potential use as biomarkers and/or molecular targets to treatment of disease.http://journal.frontiersin.org/article/10.3389/fmed.2017.00047/fullgastric cancerpolymorphismsdesoxyribonucleic acid methylationinflammationderegulation and overexpression/gene inactivation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gonzalo Castillo-Rojas Claudia I. Rivas-Ortiz Yolanda Lopez-Vidal Luis Jose Rene Arredondo-Hernandez |
spellingShingle |
Gonzalo Castillo-Rojas Claudia I. Rivas-Ortiz Yolanda Lopez-Vidal Luis Jose Rene Arredondo-Hernandez Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection Frontiers in Medicine gastric cancer polymorphisms desoxyribonucleic acid methylation inflammation deregulation and overexpression/gene inactivation |
author_facet |
Gonzalo Castillo-Rojas Claudia I. Rivas-Ortiz Yolanda Lopez-Vidal Luis Jose Rene Arredondo-Hernandez |
author_sort |
Gonzalo Castillo-Rojas |
title |
Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection |
title_short |
Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection |
title_full |
Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection |
title_fullStr |
Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection |
title_full_unstemmed |
Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection |
title_sort |
genetic alterations in gastric cancer associated with helicobacter pylori infection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2017-05-01 |
description |
Gastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in Mexico. Causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. Recent molecular studies have transgressed a number of genes involved in gastric carcinogenesis. The aim of this review is to understand the recent basics of gene expression in the development of the process of gastric carcinogenesis. Genetic variants, polymorphisms, desoxyribonucleic acid methylation, and genes involved in mediating inflammation have been associated with the development of gastric carcinogenesis. Recently, these genes (interleukin 10, Il-17, mucin 1, β-catenin, CDX1, SMAD4, SERPINE1, hypoxia-inducible factor 1 subunit alpha, GSK3β, CDH17, matrix metalloproteinase 7, RUNX3, RASSF1A, TFF1, HAI-2, and COX-2) have been studied in association with oncogenic activation or inactivation of tumor suppressor genes. All these mechanisms have been investigated to elucidate the process of gastric carcinogenesis, as well as their potential use as biomarkers and/or molecular targets to treatment of disease. |
topic |
gastric cancer polymorphisms desoxyribonucleic acid methylation inflammation deregulation and overexpression/gene inactivation |
url |
http://journal.frontiersin.org/article/10.3389/fmed.2017.00047/full |
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