Electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestations
Abstract Background Neuropsychiatric manifestations are frequently reported in systemic lupus erythematosus (SLE) patients. This study was done to describe electroencephalographic (EEG) findings in SLE patients with neuropsychiatric manifestation (NPSLE). Results Among 60 SLE patients, there were 50...
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doaj-698130d0c1344c23bd75ac1abb6529532020-12-06T12:33:47ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982020-12-013211810.1186/s43162-020-00012-1Electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestationsHowaida E. Mansour0Reem A. Habeeb1Noran O. El-Azizi2Heba H. Afeefy3Marwa A. Nassef4Ahmed A. Abd Alkader5Naglaa Afifi6Department of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams UniversityDepartment of Neurology medicine, Faculty of Medicine, Ain Shams UniversityDepartment of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams UniversityDepartment of Neurology medicine, Faculty of Medicine, Ain Shams UniversityDepartment of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams UniversityDepartment of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams UniversityDepartment of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams UniversityAbstract Background Neuropsychiatric manifestations are frequently reported in systemic lupus erythematosus (SLE) patients. This study was done to describe electroencephalographic (EEG) findings in SLE patients with neuropsychiatric manifestation (NPSLE). Results Among 60 SLE patients, there were 50 females (83.3%) and 10 males (16.7%). EEG abnormalities were reported in 12 patients out of 30 (40%) with NPSLE, while all patients with non-NPSLE (n = 30) had no EEG abnormalities; diffuse slowing (20%) was the most common abnormalities, followed by generalized epileptiform activity (13.3%), and lastly temporal epileptiform activity (6.7%). Seizure was the most reported neuropsychiatric disorder in 13 patients (43.3%); 8 of them had abnormal EEG (61.5%). Periventricular white matter lesion (23.3%) followed by infarction (13.3%) were the most common MRI brain findings among 53.3% of NPSLE group. Half of the cases with EEG abnormality had normal brain MRI. SLEDAI score and ACL IgM positivity were higher in the NPSLE group than the non-NPSLE group. EEG is not a sensitive or specific test for detecting NPSLE with sensitivity (37.5%) and specificity (57.1%). Conclusion Not all patients with NPSLE must have abnormal brain MRI or EEG. EEG is a useful assistant tool in the assessment of different manifestations of NPSLE, but it cannot be used as a screening test alone and must be supplemented by neuroimaging studies.https://doi.org/10.1186/s43162-020-00012-1ElectroencephalographySystemic lupus erythematosusNeuropsychiatric manifestations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Howaida E. Mansour Reem A. Habeeb Noran O. El-Azizi Heba H. Afeefy Marwa A. Nassef Ahmed A. Abd Alkader Naglaa Afifi |
spellingShingle |
Howaida E. Mansour Reem A. Habeeb Noran O. El-Azizi Heba H. Afeefy Marwa A. Nassef Ahmed A. Abd Alkader Naglaa Afifi Electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestations The Egyptian Journal of Internal Medicine Electroencephalography Systemic lupus erythematosus Neuropsychiatric manifestations |
author_facet |
Howaida E. Mansour Reem A. Habeeb Noran O. El-Azizi Heba H. Afeefy Marwa A. Nassef Ahmed A. Abd Alkader Naglaa Afifi |
author_sort |
Howaida E. Mansour |
title |
Electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestations |
title_short |
Electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestations |
title_full |
Electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestations |
title_fullStr |
Electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestations |
title_full_unstemmed |
Electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestations |
title_sort |
electroencephalography in systemic lupus erythematosus patients with neuropsychiatric manifestations |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Internal Medicine |
issn |
1110-7782 2090-9098 |
publishDate |
2020-12-01 |
description |
Abstract Background Neuropsychiatric manifestations are frequently reported in systemic lupus erythematosus (SLE) patients. This study was done to describe electroencephalographic (EEG) findings in SLE patients with neuropsychiatric manifestation (NPSLE). Results Among 60 SLE patients, there were 50 females (83.3%) and 10 males (16.7%). EEG abnormalities were reported in 12 patients out of 30 (40%) with NPSLE, while all patients with non-NPSLE (n = 30) had no EEG abnormalities; diffuse slowing (20%) was the most common abnormalities, followed by generalized epileptiform activity (13.3%), and lastly temporal epileptiform activity (6.7%). Seizure was the most reported neuropsychiatric disorder in 13 patients (43.3%); 8 of them had abnormal EEG (61.5%). Periventricular white matter lesion (23.3%) followed by infarction (13.3%) were the most common MRI brain findings among 53.3% of NPSLE group. Half of the cases with EEG abnormality had normal brain MRI. SLEDAI score and ACL IgM positivity were higher in the NPSLE group than the non-NPSLE group. EEG is not a sensitive or specific test for detecting NPSLE with sensitivity (37.5%) and specificity (57.1%). Conclusion Not all patients with NPSLE must have abnormal brain MRI or EEG. EEG is a useful assistant tool in the assessment of different manifestations of NPSLE, but it cannot be used as a screening test alone and must be supplemented by neuroimaging studies. |
topic |
Electroencephalography Systemic lupus erythematosus Neuropsychiatric manifestations |
url |
https://doi.org/10.1186/s43162-020-00012-1 |
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