Inflammation in COPD: a link to systemic comorbidities
Chronic obstructive pulmonary disease (COPD) has been defined as a preventable and treatable disease characterised by progressive airflow limitation that is not fully reversible and associated with an abnormal inflammatory response in the lungs. Results from a large number of recent studies have cha...
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European Respiratory Society
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doaj-698c607c9dee4a47a0d64d128a183a122020-11-25T01:12:35ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172007-09-01161059197Inflammation in COPD: a link to systemic comorbiditiesS. I. RennardChronic obstructive pulmonary disease (COPD) has been defined as a preventable and treatable disease characterised by progressive airflow limitation that is not fully reversible and associated with an abnormal inflammatory response in the lungs. Results from a large number of recent studies have characterised the inflammatory processes underlying COPD. Inflammatory cells, most notably CD8+ T-lymphocytes, macrophages and neutrophils, as well as a large number of chemokines, cytokines and proteinases, are believed to play a role. The inflammatory processes in COPD contribute to remodelling of pulmonary tissues, leading to the irreversible airflow limitation characteristic of this disease. Inflammation may also contribute to the comorbidities often observed in COPD patients. Patients with COPD often have cardiovascular disease, changes in body composition, osteoporosis and anaemia. The same inflammatory processes that characterise COPD are also risk factors for these comorbidities. Ongoing studies are evaluating a wide range of new therapies for chronic obstructive pulmonary disease. Some of these have the potential to blunt the inflammatory processes underlying chronic obstructive pulmonary disease and potentially the associated comorbid conditions. These therapies may significantly improve survival, function and quality of life for patients with this disease.http://err.ersjournals.com/cgi/content/full/16/105/91Chronic obstructive pulmonary diseaseinflammationrespiratory diseasesmoking cessationsystemic diseasesystemic inflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. I. Rennard |
spellingShingle |
S. I. Rennard Inflammation in COPD: a link to systemic comorbidities European Respiratory Review Chronic obstructive pulmonary disease inflammation respiratory disease smoking cessation systemic disease systemic inflammation |
author_facet |
S. I. Rennard |
author_sort |
S. I. Rennard |
title |
Inflammation in COPD: a link to systemic comorbidities |
title_short |
Inflammation in COPD: a link to systemic comorbidities |
title_full |
Inflammation in COPD: a link to systemic comorbidities |
title_fullStr |
Inflammation in COPD: a link to systemic comorbidities |
title_full_unstemmed |
Inflammation in COPD: a link to systemic comorbidities |
title_sort |
inflammation in copd: a link to systemic comorbidities |
publisher |
European Respiratory Society |
series |
European Respiratory Review |
issn |
0905-9180 1600-0617 |
publishDate |
2007-09-01 |
description |
Chronic obstructive pulmonary disease (COPD) has been defined as a preventable and treatable disease characterised by progressive airflow limitation that is not fully reversible and associated with an abnormal inflammatory response in the lungs. Results from a large number of recent studies have characterised the inflammatory processes underlying COPD. Inflammatory cells, most notably CD8+ T-lymphocytes, macrophages and neutrophils, as well as a large number of chemokines, cytokines and proteinases, are believed to play a role. The inflammatory processes in COPD contribute to remodelling of pulmonary tissues, leading to the irreversible airflow limitation characteristic of this disease. Inflammation may also contribute to the comorbidities often observed in COPD patients. Patients with COPD often have cardiovascular disease, changes in body composition, osteoporosis and anaemia. The same inflammatory processes that characterise COPD are also risk factors for these comorbidities. Ongoing studies are evaluating a wide range of new therapies for chronic obstructive pulmonary disease. Some of these have the potential to blunt the inflammatory processes underlying chronic obstructive pulmonary disease and potentially the associated comorbid conditions. These therapies may significantly improve survival, function and quality of life for patients with this disease. |
topic |
Chronic obstructive pulmonary disease inflammation respiratory disease smoking cessation systemic disease systemic inflammation |
url |
http://err.ersjournals.com/cgi/content/full/16/105/91 |
work_keys_str_mv |
AT sirennard inflammationincopdalinktosystemiccomorbidities |
_version_ |
1725165515380359168 |