Calhex231 Ameliorates Cardiac Hypertrophy by Inhibiting Cellular Autophagy in Vivo and in Vitro

Calhex231 Ameliorates Cardiac Hypertrophy by Inhibiting Cellular Autophagy in Vivo and in Vitro

Background/Aims: Intracellular calcium concentration ([Ca2+]i) homeostasis, an initial factor of cardiac hypertrophy, is regulated by the calcium-sensing receptor (CaSR) and is associated with the formation of autolysosomes. The aim of this study was to investigate the role of Calhex231, a CaSR inhi...

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Bibliographic Details
Main Authors: Lei Liu, Chao Wang, Dianjun Sun, Shuangquan Jiang, Hong Li, Weihua Zhang, Yajun Zhao, Yuhui Xi, Sa Shi, Fanghao Lu, Ye Tian, Changqing Xu, Lina Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Calcium-sensing receptor (CaSR)
Calhex231
Autophagy
Cardiac hypertrophy
Online Access:http://www.karger.com/Article/FullText/430322

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