A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells.
The inactivation of p53 creates a major challenge for inducing apoptosis in cancer cells. An attractive strategy is to identify and subsequently target the survival signals in p53 defective cancer cells. Here we uncover a RUNX2-mediated survival signal in p53 defective cancer cells. The inhibition o...
Main Authors: | Min Hwa Shin, Yunlong He, Eryney Marrogi, Sajida Piperdi, Ling Ren, Chand Khanna, Richard Gorlick, Chengyu Liu, Jing Huang |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-02-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4771715?pdf=render |
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