Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication
A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication. A number of positive allosteric modulators (PAMs)...
Main Authors: | Jide Tian, Hoa Dang, Blake Middleton, Daniel L. Kaufman |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-03-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-00515-y |
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