Endobronchial metastases 20 years after prostate cancer excision
A 78-year-old Japanese man who had undergone total prostatectomy for prostate cancer (pT3cN1M0, Gleason score 3 + 3) 20 years previously was referred to the Respiratory Medicine Department of our institution because of a 1-week history of chest pain and cough. Computed tomography showed multiple sma...
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doaj-69a5f2643e784aa9beeb305184ee2d1f2020-11-25T01:27:47ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-0127Endobronchial metastases 20 years after prostate cancer excisionYukihisa Hatakeyama0Sho Yoshimura1Taira Ninomaru2Shodai Fujimoto3Rei Takamiya4Kayoko Okamura5Nobuya Sano6Hisashi Ohnishi7Department of Respiratory Medicine, Akashi Medical Center, 743-33 Okubocho Yagi, Akashi, Hyogo, 674-0063, Japan; Corresponding author.Department of Respiratory Medicine, Akashi Medical Center, 743-33 Okubocho Yagi, Akashi, Hyogo, 674-0063, JapanDepartment of Respiratory Medicine, Akashi Medical Center, 743-33 Okubocho Yagi, Akashi, Hyogo, 674-0063, JapanDepartment of Respiratory Medicine, Akashi Medical Center, 743-33 Okubocho Yagi, Akashi, Hyogo, 674-0063, JapanDepartment of Respiratory Medicine, Akashi Medical Center, 743-33 Okubocho Yagi, Akashi, Hyogo, 674-0063, JapanDepartment of Respiratory Medicine, Akashi Medical Center, 743-33 Okubocho Yagi, Akashi, Hyogo, 674-0063, JapanDepartment of Pathology, Akashi Medical Center, 743-33 Okubocho Yagi, Akashi, Hyogo, 674-0063, JapanDepartment of Respiratory Medicine, Akashi Medical Center, 743-33 Okubocho Yagi, Akashi, Hyogo, 674-0063, JapanA 78-year-old Japanese man who had undergone total prostatectomy for prostate cancer (pT3cN1M0, Gleason score 3 + 3) 20 years previously was referred to the Respiratory Medicine Department of our institution because of a 1-week history of chest pain and cough. Computed tomography showed multiple small nodules and mediastinal lymph node enlargement. Bronchoscopy revealed multiple soft polypoid masses and obstruction of the lingular segment. Prostate-specific antigen (PSA) concentrations had increased markedly from 0.48 ng/mL in 2014 to 741 ng/mL in 2018. The diagnosis of prostatic cancer metastases was confirmed by revealing the presence of PSA via immunohistological staining of a bronchoscopically obtained biopsy of one of the masses. The patient had not been attending scheduled follow-up visits for the past 4 years. Treatment with degarelix (a gonadotropin-releasing hormone) was started, and the PSA concentration decreased dramatically (29 ng/mL). Metastases from prostate cancer are rarely first diagnosed two decades after radical prostatectomy. This patient illustrates the importance of obtaining a complete medical history. Keywords: Bronchoscopy, Prostate cancer, Endobronchial metastases, Metastatic lung cancer, PSAhttp://www.sciencedirect.com/science/article/pii/S2213007119300048 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yukihisa Hatakeyama Sho Yoshimura Taira Ninomaru Shodai Fujimoto Rei Takamiya Kayoko Okamura Nobuya Sano Hisashi Ohnishi |
spellingShingle |
Yukihisa Hatakeyama Sho Yoshimura Taira Ninomaru Shodai Fujimoto Rei Takamiya Kayoko Okamura Nobuya Sano Hisashi Ohnishi Endobronchial metastases 20 years after prostate cancer excision Respiratory Medicine Case Reports |
author_facet |
Yukihisa Hatakeyama Sho Yoshimura Taira Ninomaru Shodai Fujimoto Rei Takamiya Kayoko Okamura Nobuya Sano Hisashi Ohnishi |
author_sort |
Yukihisa Hatakeyama |
title |
Endobronchial metastases 20 years after prostate cancer excision |
title_short |
Endobronchial metastases 20 years after prostate cancer excision |
title_full |
Endobronchial metastases 20 years after prostate cancer excision |
title_fullStr |
Endobronchial metastases 20 years after prostate cancer excision |
title_full_unstemmed |
Endobronchial metastases 20 years after prostate cancer excision |
title_sort |
endobronchial metastases 20 years after prostate cancer excision |
publisher |
Elsevier |
series |
Respiratory Medicine Case Reports |
issn |
2213-0071 |
publishDate |
2019-01-01 |
description |
A 78-year-old Japanese man who had undergone total prostatectomy for prostate cancer (pT3cN1M0, Gleason score 3 + 3) 20 years previously was referred to the Respiratory Medicine Department of our institution because of a 1-week history of chest pain and cough. Computed tomography showed multiple small nodules and mediastinal lymph node enlargement. Bronchoscopy revealed multiple soft polypoid masses and obstruction of the lingular segment. Prostate-specific antigen (PSA) concentrations had increased markedly from 0.48 ng/mL in 2014 to 741 ng/mL in 2018. The diagnosis of prostatic cancer metastases was confirmed by revealing the presence of PSA via immunohistological staining of a bronchoscopically obtained biopsy of one of the masses. The patient had not been attending scheduled follow-up visits for the past 4 years. Treatment with degarelix (a gonadotropin-releasing hormone) was started, and the PSA concentration decreased dramatically (29 ng/mL). Metastases from prostate cancer are rarely first diagnosed two decades after radical prostatectomy. This patient illustrates the importance of obtaining a complete medical history. Keywords: Bronchoscopy, Prostate cancer, Endobronchial metastases, Metastatic lung cancer, PSA |
url |
http://www.sciencedirect.com/science/article/pii/S2213007119300048 |
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