A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain

A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain

In the European Union, the high-concentration capsaicin patch is licensed for the management of neuropathic pain conditions in nondiabetic patients, including postherpetic neuralgia (PHN) and HIV-associated distal sensory polyneuropathy (HIV-DSP). However, in the USA, the Food and Drug Administratio...

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Main Authors: Ganesan Baranidharan, Sangeeta Das, Arun Bhaskar
Format: Article
Language:English
Published: SAGE Publishing 2013-09-01
Series:Therapeutic Advances in Neurological Disorders
Online Access:https://doi.org/10.1177/1756285613496862
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spelling doaj-69b3ca8aabf44412b7d9eb75512afb2f2020-11-25T03:33:53ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28561756-28642013-09-01610.1177/1756285613496862A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic painGanesan BaranidharanSangeeta DasArun BhaskarIn the European Union, the high-concentration capsaicin patch is licensed for the management of neuropathic pain conditions in nondiabetic patients, including postherpetic neuralgia (PHN) and HIV-associated distal sensory polyneuropathy (HIV-DSP). However, in the USA, the Food and Drug Administration approved its use only in PHN patients. Capsaicin is a transient receptor potential vanilloid-1 agonist, which increases the intracellular calcium ion concentration. This triggers calcium-dependent protease enzymes causing cytoskeletal breakdown and leads to the loss of cellular integrity and ‘defunctionalization’ of nociceptor fibres. Efficacy and therapeutic effect has been shown in several clinical studies of PHN and HIV-DSP. The high-concentration capsaicin patch and its practical application are different from low-concentration creams; one application can help for up to 3 months. The process of setting up of a service to use the capsaicin 8% patch is also discussed.https://doi.org/10.1177/1756285613496862
collection DOAJ
language English
format Article
sources DOAJ
author Ganesan Baranidharan
Sangeeta Das
Arun Bhaskar
spellingShingle Ganesan Baranidharan
Sangeeta Das
Arun Bhaskar
A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain
Therapeutic Advances in Neurological Disorders
author_facet Ganesan Baranidharan
Sangeeta Das
Arun Bhaskar
author_sort Ganesan Baranidharan
title A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain
title_short A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain
title_full A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain
title_fullStr A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain
title_full_unstemmed A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain
title_sort review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain
publisher SAGE Publishing
series Therapeutic Advances in Neurological Disorders
issn 1756-2856
1756-2864
publishDate 2013-09-01
description In the European Union, the high-concentration capsaicin patch is licensed for the management of neuropathic pain conditions in nondiabetic patients, including postherpetic neuralgia (PHN) and HIV-associated distal sensory polyneuropathy (HIV-DSP). However, in the USA, the Food and Drug Administration approved its use only in PHN patients. Capsaicin is a transient receptor potential vanilloid-1 agonist, which increases the intracellular calcium ion concentration. This triggers calcium-dependent protease enzymes causing cytoskeletal breakdown and leads to the loss of cellular integrity and ‘defunctionalization’ of nociceptor fibres. Efficacy and therapeutic effect has been shown in several clinical studies of PHN and HIV-DSP. The high-concentration capsaicin patch and its practical application are different from low-concentration creams; one application can help for up to 3 months. The process of setting up of a service to use the capsaicin 8% patch is also discussed.
url https://doi.org/10.1177/1756285613496862
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