A Simple Cardiovascular Model for the Study of Hemorrhagic Shock
Hemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well. Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved. This paper introduce...
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Series: | Computational and Mathematical Methods in Medicine |
Online Access: | http://dx.doi.org/10.1155/2020/7936895 |
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doaj-69b93c3e043c41d1ae300807d920a3812021-01-11T02:21:46ZengHindawi LimitedComputational and Mathematical Methods in Medicine1748-67182020-01-01202010.1155/2020/7936895A Simple Cardiovascular Model for the Study of Hemorrhagic ShockLuciano Curcio0Laura D’Orsi1Fabio Cibella2Linn Wagnert-Avraham3Dean Nachman4Andrea De Gaetano5National Research Council of ItalyNational Research Council of ItalyNational Research Council of ItalyInstitute for Research in Military Medicine (IRMM)Institute for Research in Military Medicine (IRMM)National Research Council of ItalyHemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well. Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved. This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations. Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. This model is capable of replicating the changes in mean arterial pressure, heart rate, and cardiac output after the onset of bleeding (as observed in four experimental laboratory animals) and achieves a reasonable compromise between an overly detailed depiction of relevant mechanisms, on the one hand, and model simplicity, on the other. The former would require considerable simulations and entail burdensome interpretations. From a clinical standpoint, the goals of the new model are to predict survival and optimize the timing of therapy, in both civilian and military scenarios.http://dx.doi.org/10.1155/2020/7936895 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luciano Curcio Laura D’Orsi Fabio Cibella Linn Wagnert-Avraham Dean Nachman Andrea De Gaetano |
spellingShingle |
Luciano Curcio Laura D’Orsi Fabio Cibella Linn Wagnert-Avraham Dean Nachman Andrea De Gaetano A Simple Cardiovascular Model for the Study of Hemorrhagic Shock Computational and Mathematical Methods in Medicine |
author_facet |
Luciano Curcio Laura D’Orsi Fabio Cibella Linn Wagnert-Avraham Dean Nachman Andrea De Gaetano |
author_sort |
Luciano Curcio |
title |
A Simple Cardiovascular Model for the Study of Hemorrhagic Shock |
title_short |
A Simple Cardiovascular Model for the Study of Hemorrhagic Shock |
title_full |
A Simple Cardiovascular Model for the Study of Hemorrhagic Shock |
title_fullStr |
A Simple Cardiovascular Model for the Study of Hemorrhagic Shock |
title_full_unstemmed |
A Simple Cardiovascular Model for the Study of Hemorrhagic Shock |
title_sort |
simple cardiovascular model for the study of hemorrhagic shock |
publisher |
Hindawi Limited |
series |
Computational and Mathematical Methods in Medicine |
issn |
1748-6718 |
publishDate |
2020-01-01 |
description |
Hemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well. Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved. This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations. Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. This model is capable of replicating the changes in mean arterial pressure, heart rate, and cardiac output after the onset of bleeding (as observed in four experimental laboratory animals) and achieves a reasonable compromise between an overly detailed depiction of relevant mechanisms, on the one hand, and model simplicity, on the other. The former would require considerable simulations and entail burdensome interpretations. From a clinical standpoint, the goals of the new model are to predict survival and optimize the timing of therapy, in both civilian and military scenarios. |
url |
http://dx.doi.org/10.1155/2020/7936895 |
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