Non-Covalent Associates of siRNAs and AuNPs Enveloped with Lipid Layer and Doped with Amphiphilic Peptide for Efficient siRNA Delivery

Non-Covalent Associates of siRNAs and AuNPs Enveloped with Lipid Layer and Doped with Amphiphilic Peptide for Efficient siRNA Delivery

Elaboration of non-viral vehicles for delivery of therapeutic nucleic acids, in particular siRNA, into a cell is an actively growing field. Gold nanoparticles (AuNPs) occupy a noticeable place in these studies, and various nanoconstructions containing AuNPs are reported. We aimed our work to the rat...

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Bibliographic Details
Main Authors: Julia Poletaeva, Ilya Dovydenko, Anna Epanchintseva, Kseniya Korchagina, Dmitrii Pyshnyi, Evgeny Apartsin, Elena Ryabchikova, Inna Pyshnaya
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
siRNA
non-covalent binding with AuNPs
lipid enveloped AuNPs
pH-sensitive lipidoid
GFP-silencing
Online Access:http://www.mdpi.com/1422-0067/19/7/2096

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