Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study
Abstract Background Orofacial clefts (OFCs) comprise a wide range of malformations, including cleft lip, cleft palate, and cleft lip with cleft palate, which can vary in terms of etiology, severity, and disease burden. Objective(s) This study aimed to evaluate the correlation between various risk fa...
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doaj-69d354e44bd6471bb1f3031aad767a9a2020-11-25T03:59:53ZengSpringerOpenMaxillofacial Plastic and Reconstructive Surgery2288-85862020-08-014211610.1186/s40902-020-00270-7Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control studyBehzad Cheshmi0Zahra Jafari1Mohammad Ali Naseri2Heidar Ali Davari3Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Broujerd Branch, Islamic Azad UniversityDepartment of Oral and Maxillofacial Medicine, Faculty of Dentistry, Broujerd Branch, Islamic Azad UniversityDepartment of Orthodontics and Dentofacial Orthopedics, Broujerd Branch, Islamic Azad UniversityDepartment of Oral and Maxillofacial Medicine, Faculty of Dentistry, Broujerd Branch, Islamic Azad UniversityAbstract Background Orofacial clefts (OFCs) comprise a wide range of malformations, including cleft lip, cleft palate, and cleft lip with cleft palate, which can vary in terms of etiology, severity, and disease burden. Objective(s) This study aimed to evaluate the correlation between various risk factors and orofacial cleft disorder spectrum in newborns. Study design A total of 323 cases and 400 controls were enrolled in this study and evaluated in terms of the maternal history of abortion or miscarriage, child’s sex, maternal and paternal age, maternal history of systemic disease, history of medication therapy during pregnancy, birth order, consanguineous marriage, and complications during pregnancy. Results Analysis of the results suggested that consanguineous marriage, a maternal history of abortion/miscarriage, and complications during pregnancy could potentially increase the risk of OFCs in children (P < 0.05). However, the analyses revealed that the other variables could not potentially increase the risk of OFCs (P > 0.05). Conclusion(s) Multiple cofactors may simultaneously contribute to the formation of such abnormalities; therefore, a comprehensive, multidisciplinary care program is necessary to ensure a successful pregnancy period and the birth of a healthy newborn.http://link.springer.com/article/10.1186/s40902-020-00270-7Cleft lipCleft palateOrofacial cleftMiscarriageAbortionPregnancy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Behzad Cheshmi Zahra Jafari Mohammad Ali Naseri Heidar Ali Davari |
spellingShingle |
Behzad Cheshmi Zahra Jafari Mohammad Ali Naseri Heidar Ali Davari Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study Maxillofacial Plastic and Reconstructive Surgery Cleft lip Cleft palate Orofacial cleft Miscarriage Abortion Pregnancy |
author_facet |
Behzad Cheshmi Zahra Jafari Mohammad Ali Naseri Heidar Ali Davari |
author_sort |
Behzad Cheshmi |
title |
Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study |
title_short |
Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study |
title_full |
Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study |
title_fullStr |
Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study |
title_full_unstemmed |
Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study |
title_sort |
assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study |
publisher |
SpringerOpen |
series |
Maxillofacial Plastic and Reconstructive Surgery |
issn |
2288-8586 |
publishDate |
2020-08-01 |
description |
Abstract Background Orofacial clefts (OFCs) comprise a wide range of malformations, including cleft lip, cleft palate, and cleft lip with cleft palate, which can vary in terms of etiology, severity, and disease burden. Objective(s) This study aimed to evaluate the correlation between various risk factors and orofacial cleft disorder spectrum in newborns. Study design A total of 323 cases and 400 controls were enrolled in this study and evaluated in terms of the maternal history of abortion or miscarriage, child’s sex, maternal and paternal age, maternal history of systemic disease, history of medication therapy during pregnancy, birth order, consanguineous marriage, and complications during pregnancy. Results Analysis of the results suggested that consanguineous marriage, a maternal history of abortion/miscarriage, and complications during pregnancy could potentially increase the risk of OFCs in children (P < 0.05). However, the analyses revealed that the other variables could not potentially increase the risk of OFCs (P > 0.05). Conclusion(s) Multiple cofactors may simultaneously contribute to the formation of such abnormalities; therefore, a comprehensive, multidisciplinary care program is necessary to ensure a successful pregnancy period and the birth of a healthy newborn. |
topic |
Cleft lip Cleft palate Orofacial cleft Miscarriage Abortion Pregnancy |
url |
http://link.springer.com/article/10.1186/s40902-020-00270-7 |
work_keys_str_mv |
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