The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms

• Main Authors: Spasovski Vesna, Tosić Natasa, Kostić Tatjana, Zukić Branka, Stojiljković Maja, Čolović Milica, Pavlović Sonja
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2010-01-01
• Series: Archives of Biological Sciences
• Subjects: Myeloproliferative neoplasms; FasR/FasL; JAK2 V617F mutation
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641002223S.pdf

Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the role of FasR/FasL in the pathogenesis of MPNs. We compared FasR/FasL expression between MPN patients (24) and healthy individuals using the real-time PCR assay. We found an increase of FasR expression in MPN patients. No difference was detected in FasL expression. Mutation V617F in the JAK2 gene, a hallmark of MPN, was detected in 13/24 patients. We found that neither FasR nor FasL expression were related to the presence of JAK2 V617F mutation.