Blockade of TNFα to Improve Human CD34+ Cell Repopulating Activity in Allogeneic Stem Cell Transplantation

Blockade of TNFα to Improve Human CD34+ Cell Repopulating Activity in Allogeneic Stem Cell Transplantation

Early release of TNFα after hematopoietic stem cell transplantation (HSCT) correlates with development of acute graft-vs.-host disease (GVHD). Here we tested the effect of TNFα and alloreactive T cells on early hematopoietic HSC genotype and function. Addition of TNFα (10 ng/ml) in liquid cultures w...

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Bibliographic Details
Main Authors: Vitalyi Senyuk, Pritesh Patel, Nadim Mahmud, Damiano Rondelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
CD34
TNFα
transplantation
GVHD
T cells
repopulating activity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03186/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03186/full

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