Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes
Despite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign ce...
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2021-01-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2020.617647/full |
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doaj-69de12fd344f43c2a6978ba920a272ce2021-01-13T04:53:02ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692021-01-01710.3389/fvets.2020.617647617647Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine OutcomesJ. Lacy Kamm0Christopher B. Riley1Natalie Parlane2Erica K Gee3C. Wayne McIlwraith4School of Veterinary Science, Massey University, Palmerston North, New ZealandSchool of Veterinary Science, Massey University, Palmerston North, New ZealandHopkirk Laboratory, AgResearch, Palmerston North, New ZealandSchool of Veterinary Science, Massey University, Palmerston North, New ZealandOrthopaedic Research Center, C. Wayne McIlwraith Translational Medical Institute, Colorado State University, Fort Collins, CO, United StatesDespite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign cells, and later, the adaptive immune system, a delayed response that causes cell death due to recognition of specific alloantigens by host cells and antibodies. This review describes the actions of MSCs to both suppress and activate the different arms of the immune system. We then review the survival and effectiveness of the currently used allogeneic MSC treatments.https://www.frontiersin.org/articles/10.3389/fvets.2020.617647/fullallogeneicmesenchymal stromal cellequineimmunelymphocyte |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
J. Lacy Kamm Christopher B. Riley Natalie Parlane Erica K Gee C. Wayne McIlwraith |
spellingShingle |
J. Lacy Kamm Christopher B. Riley Natalie Parlane Erica K Gee C. Wayne McIlwraith Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes Frontiers in Veterinary Science allogeneic mesenchymal stromal cell equine immune lymphocyte |
author_facet |
J. Lacy Kamm Christopher B. Riley Natalie Parlane Erica K Gee C. Wayne McIlwraith |
author_sort |
J. Lacy Kamm |
title |
Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes |
title_short |
Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes |
title_full |
Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes |
title_fullStr |
Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes |
title_full_unstemmed |
Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes |
title_sort |
interactions between allogeneic mesenchymal stromal cells and the recipient immune system: a comparative review with relevance to equine outcomes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Veterinary Science |
issn |
2297-1769 |
publishDate |
2021-01-01 |
description |
Despite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign cells, and later, the adaptive immune system, a delayed response that causes cell death due to recognition of specific alloantigens by host cells and antibodies. This review describes the actions of MSCs to both suppress and activate the different arms of the immune system. We then review the survival and effectiveness of the currently used allogeneic MSC treatments. |
topic |
allogeneic mesenchymal stromal cell equine immune lymphocyte |
url |
https://www.frontiersin.org/articles/10.3389/fvets.2020.617647/full |
work_keys_str_mv |
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