Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents
Objectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sultan Qaboos University
2018-12-01
|
Series: | Sultan Qaboos University Medical Journal |
Online Access: | https://journals.squ.edu.om/index.php/squmj/article/view/2848 |
id |
doaj-69e63fde25dd44d1b4a1dfa7187ae93b |
---|---|
record_format |
Article |
spelling |
doaj-69e63fde25dd44d1b4a1dfa7187ae93b2020-11-25T02:43:13ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal 2075-051X2075-05282018-12-0118329129810.18295/squmj.2018.18.03.0052454Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in AdolescentsMaría D. Martínez-Martínez0Hugo Mendieta-Zerón1Luis Celis2Cristian F. Layton-Tovar3Rocío Torres-García4Laura E. Gutiérrez-Pliego5Eneida Camarillo-Romero6José D. Garduño-García7María D. Camarillo-Romero8Faculty of Nursing, Autonomous University of Mexico State, Toluca, MexicoFaculty of Medicine, Autonomous University of Mexico State, Toluca, MexicoFaculty of Medicine, Universidad de la Sabana, Chía, ColombiaCoordination of High Specialty Hospitals, Ministry of Health, Toluca, MexicoCenter for Research in Medical Sciences, Autonomous University of Mexico State, Toluca, MexicoCenter for Research in Medical Sciences, Autonomous University of Mexico State, Toluca, MexicoCenter for Research in Medical Sciences, Autonomous University of Mexico State, Toluca, MexicoCenter for Research in Medical Sciences, Autonomous University of Mexico State, Toluca, MexicoCenter for Research in Medical Sciences, Autonomous University of Mexico State, Toluca, MexicoObjectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801282 single nucleotide polymorphisms (SNPs) as indicators of body mass index in adolescents. Methods: This cross-sectional study was conducted between September and December 2016 in Toluca, Mexico. A total of 71 students between 14–18 years old were included. Various anthropometric and laboratory measurements were collected, including lipid profile, glucose, insulin and adipokine levels and HOMA index. The degree of association between variables was evaluated with regards to the presence/absence of the SNPs. Results: Leptin levels were significantly higher among female students (P = 0.001), although adiponectin levels did not differ significantly (P = 0.060). There were significant positive correlations between insulin levels and HOMA index with FTO (r = 0.391; P = 0.007 and r = 0.413; P = 0.005, respectively) and PPARγ (r = 0.529; P = 0.007 and r = 0.537; P = 0.007, respectively) SNPs. Leptin showed a significant positive correlation in the presence of PPARγ (r = 0.483; P = 0.007) or in the absence of both SNPs (r = 0.627; P = 0.039). However, adiponectin was significantly negatively correlated in the presence of FTO, either alone (r = −0.333; P = 0.024) or in combination with PPARγ (r = −0.616; P = 0.043). Conclusion: The presence of FTO and/or PPARγ SNPs might be related to a genetic predisposition to metabolic syndrome. Keywords: Obesity; Body Mass Index; Single Nucleotide Polymorphisms; Fat Mass and Obesity Associated Protein, Human; Peroxisome Proliferator-Activated Receptor gamma; Adipokines.https://journals.squ.edu.om/index.php/squmj/article/view/2848 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María D. Martínez-Martínez Hugo Mendieta-Zerón Luis Celis Cristian F. Layton-Tovar Rocío Torres-García Laura E. Gutiérrez-Pliego Eneida Camarillo-Romero José D. Garduño-García María D. Camarillo-Romero |
spellingShingle |
María D. Martínez-Martínez Hugo Mendieta-Zerón Luis Celis Cristian F. Layton-Tovar Rocío Torres-García Laura E. Gutiérrez-Pliego Eneida Camarillo-Romero José D. Garduño-García María D. Camarillo-Romero Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents Sultan Qaboos University Medical Journal |
author_facet |
María D. Martínez-Martínez Hugo Mendieta-Zerón Luis Celis Cristian F. Layton-Tovar Rocío Torres-García Laura E. Gutiérrez-Pliego Eneida Camarillo-Romero José D. Garduño-García María D. Camarillo-Romero |
author_sort |
María D. Martínez-Martínez |
title |
Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents |
title_short |
Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents |
title_full |
Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents |
title_fullStr |
Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents |
title_full_unstemmed |
Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents |
title_sort |
correlation of the homeostasis model assessment index and adiponectin, leptin and insulin levels to body mass index-associated gene polymorphisms in adolescents |
publisher |
Sultan Qaboos University |
series |
Sultan Qaboos University Medical Journal |
issn |
2075-051X 2075-0528 |
publishDate |
2018-12-01 |
description |
Objectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801282 single nucleotide polymorphisms (SNPs) as indicators of body mass index in adolescents. Methods: This cross-sectional study was conducted between September and December 2016 in Toluca, Mexico. A total of 71 students between 14–18 years old were included. Various anthropometric and laboratory measurements were collected, including lipid profile, glucose, insulin and adipokine levels and HOMA index. The degree of association between variables was evaluated with regards to the presence/absence of the SNPs. Results: Leptin levels were significantly higher among female students (P = 0.001), although adiponectin levels did not differ significantly (P = 0.060). There were significant positive correlations between insulin levels and HOMA index with FTO (r = 0.391; P = 0.007 and r = 0.413; P = 0.005, respectively) and PPARγ (r = 0.529; P = 0.007 and r = 0.537; P = 0.007, respectively) SNPs. Leptin showed a significant positive correlation in the presence of PPARγ (r = 0.483; P = 0.007) or in the absence of both SNPs (r = 0.627; P = 0.039). However, adiponectin was significantly negatively correlated in the presence of FTO, either alone (r = −0.333; P = 0.024) or in combination with PPARγ (r = −0.616; P = 0.043). Conclusion: The presence of FTO and/or PPARγ SNPs might be related to a genetic predisposition to metabolic syndrome.
Keywords: Obesity; Body Mass Index; Single Nucleotide Polymorphisms; Fat Mass and Obesity Associated Protein, Human; Peroxisome Proliferator-Activated Receptor gamma; Adipokines. |
url |
https://journals.squ.edu.om/index.php/squmj/article/view/2848 |
work_keys_str_mv |
AT mariadmartinezmartinez correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents AT hugomendietazeron correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents AT luiscelis correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents AT cristianflaytontovar correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents AT rociotorresgarcia correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents AT lauraegutierrezpliego correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents AT eneidacamarilloromero correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents AT josedgardunogarcia correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents AT mariadcamarilloromero correlationofthehomeostasismodelassessmentindexandadiponectinleptinandinsulinlevelstobodymassindexassociatedgenepolymorphismsinadolescents |
_version_ |
1724770724732731392 |