Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 si...

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Main Authors: Cheng Wang, Wenjing Xu, Jie An, Minglu Liang, Yiqing Li, Fengxiao Zhang, Qiangsong Tong, Kai Huang
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09174-1
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spelling doaj-69ede5d3fbeb44789640a5683cea514a2021-05-11T11:39:24ZengNature Publishing GroupNature Communications2041-17232019-03-0110111210.1038/s41467-019-09174-1Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2Cheng Wang0Wenjing Xu1Jie An2Minglu Liang3Yiqing Li4Fengxiao Zhang5Qiangsong Tong6Kai Huang7Clinical Center for Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyClinical Center for Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyClinical Center for Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyClinical Center for Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyClinical Center for Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyClinical Center for Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyClinical Center for Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyVascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 signaling, thus relieving repression of the osteogenic regulator Runx2.https://doi.org/10.1038/s41467-019-09174-1
collection DOAJ
language English
format Article
sources DOAJ
author Cheng Wang
Wenjing Xu
Jie An
Minglu Liang
Yiqing Li
Fengxiao Zhang
Qiangsong Tong
Kai Huang
spellingShingle Cheng Wang
Wenjing Xu
Jie An
Minglu Liang
Yiqing Li
Fengxiao Zhang
Qiangsong Tong
Kai Huang
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
Nature Communications
author_facet Cheng Wang
Wenjing Xu
Jie An
Minglu Liang
Yiqing Li
Fengxiao Zhang
Qiangsong Tong
Kai Huang
author_sort Cheng Wang
title Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_short Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_full Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_fullStr Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_full_unstemmed Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_sort poly(adp-ribose) polymerase 1 accelerates vascular calcification by upregulating runx2
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 signaling, thus relieving repression of the osteogenic regulator Runx2.
url https://doi.org/10.1038/s41467-019-09174-1
work_keys_str_mv AT chengwang polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT wenjingxu polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT jiean polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT mingluliang polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT yiqingli polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT fengxiaozhang polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT qiangsongtong polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT kaihuang polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
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