Impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adults
BACKGROUND: Glucocorticoids (GCs) may cause leukocytosis through several mechanisms. The objective of this study was to examine the impact of a single-GCs dose on total white blood cell (WBC) count, absolute neutrophil count (ANC), and absolute lymphocyte count (ALC) in hospitalized adults without b...
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2020-01-01
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doaj-69f1475d81864aecb06c87c474575a882020-11-25T02:47:28ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272020-01-0111311612110.4103/joah.joah_24_20Impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adultsSamah AlshehriKhalid EljaalyMohannad AlshibaniMichael KatzBACKGROUND: Glucocorticoids (GCs) may cause leukocytosis through several mechanisms. The objective of this study was to examine the impact of a single-GCs dose on total white blood cell (WBC) count, absolute neutrophil count (ANC), and absolute lymphocyte count (ALC) in hospitalized adults without bacterial infections. METHODS: This retrospective cohort study included hospitalized patients ≥18 years of age who received a single dose of a systemic GC (oral or intravenous methylprednisolone and hydrocortisone and oral prednisone). Total WBC count, ANC, and ALC changes over the 72 h after GC administration were evaluated. RESULTS: A total of 99 patients were included. After the administration of a single-GC dose, ALC began to drop significantly as early as the interval of 0–<6 h (median interquartile range, 0.90 [0.60–1.10], P = 0.011). ANC increased significantly as early as the interval of 6–<12 h (6.22 [4.45–7.33], P = 0.049) and continued to be significantly increased from baseline up to 42 h from GC administration. Total WBC counts significantly decreased in the 6–<12 h interval (6.90 [5.15–8.85], P = 0.03) and then increased significantly in the 12–<18 h interval (8.80 [6.50–11.95], P = 0.002). This effect on total WBC count continued to be significant until the 36-<42 h interval (10.55 [7.23–13.03], P < 0.001). CONCLUSIONS: ANC followed by WBC count increased significantly after a single-GC dose in hospitalized patients within 12 h of a single-GC dose, while a decrease in WBC and ALC was seen within the first few hours of GC dose.http://www.jahjournal.org/article.asp?issn=1658-5127;year=2020;volume=11;issue=3;spage=116;epage=121;aulast=Alshehricorticosteroidsglucocorticoidsleukocytosiswhite blood cell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samah Alshehri Khalid Eljaaly Mohannad Alshibani Michael Katz |
spellingShingle |
Samah Alshehri Khalid Eljaaly Mohannad Alshibani Michael Katz Impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adults Journal of Applied Hematology corticosteroids glucocorticoids leukocytosis white blood cell |
author_facet |
Samah Alshehri Khalid Eljaaly Mohannad Alshibani Michael Katz |
author_sort |
Samah Alshehri |
title |
Impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adults |
title_short |
Impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adults |
title_full |
Impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adults |
title_fullStr |
Impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adults |
title_full_unstemmed |
Impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adults |
title_sort |
impact of single-dose systemic glucocorticoids on blood leukocytes in hospitalized adults |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Applied Hematology |
issn |
1658-5127 |
publishDate |
2020-01-01 |
description |
BACKGROUND: Glucocorticoids (GCs) may cause leukocytosis through several mechanisms. The objective of this study was to examine the impact of a single-GCs dose on total white blood cell (WBC) count, absolute neutrophil count (ANC), and absolute lymphocyte count (ALC) in hospitalized adults without bacterial infections.
METHODS: This retrospective cohort study included hospitalized patients ≥18 years of age who received a single dose of a systemic GC (oral or intravenous methylprednisolone and hydrocortisone and oral prednisone). Total WBC count, ANC, and ALC changes over the 72 h after GC administration were evaluated.
RESULTS: A total of 99 patients were included. After the administration of a single-GC dose, ALC began to drop significantly as early as the interval of 0–<6 h (median interquartile range, 0.90 [0.60–1.10], P = 0.011). ANC increased significantly as early as the interval of 6–<12 h (6.22 [4.45–7.33], P = 0.049) and continued to be significantly increased from baseline up to 42 h from GC administration. Total WBC counts significantly decreased in the 6–<12 h interval (6.90 [5.15–8.85], P = 0.03) and then increased significantly in the 12–<18 h interval (8.80 [6.50–11.95], P = 0.002). This effect on total WBC count continued to be significant until the 36-<42 h interval (10.55 [7.23–13.03], P < 0.001).
CONCLUSIONS: ANC followed by WBC count increased significantly after a single-GC dose in hospitalized patients within 12 h of a single-GC dose, while a decrease in WBC and ALC was seen within the first few hours of GC dose. |
topic |
corticosteroids glucocorticoids leukocytosis white blood cell |
url |
http://www.jahjournal.org/article.asp?issn=1658-5127;year=2020;volume=11;issue=3;spage=116;epage=121;aulast=Alshehri |
work_keys_str_mv |
AT samahalshehri impactofsingledosesystemicglucocorticoidsonbloodleukocytesinhospitalizedadults AT khalideljaaly impactofsingledosesystemicglucocorticoidsonbloodleukocytesinhospitalizedadults AT mohannadalshibani impactofsingledosesystemicglucocorticoidsonbloodleukocytesinhospitalizedadults AT michaelkatz impactofsingledosesystemicglucocorticoidsonbloodleukocytesinhospitalizedadults |
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1724753348244013056 |