Urinary Clusterin Is Upregulated in Nephropathia Epidemica
Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using B...
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doaj-69f30c3b81804ba392e15be1c7c096a62020-11-24T21:24:44ZengHindawi LimitedDisease Markers0278-02401875-86302018-01-01201810.1155/2018/86585078658507Urinary Clusterin Is Upregulated in Nephropathia EpidemicaEkaterina V. Martynova0Adelya N. Maksudova1Venera G. Shakirova2Sayar R. Abdulkhakov3Ilsiyar M. Khaertynova4Vladimir A. Anokhin5Vilena V. Ivanova6Ilesanmi M. Abiola7Ekaterina E. Garanina8Leisan G. Tazetdinova9Aigul H. Valiullina10Svetlana F. Khaiboullina11Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, RussiaKazan State Medical University, Kazan, Republic of Tatarstan, RussiaKazan State Medical Academy, Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, RussiaKazan State Medical Academy, Kazan, Republic of Tatarstan, RussiaKazan State Medical University, Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, RussiaKidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxicity panels 1 and 2. To determine the disease specificity, kidney damage biomarkers were also analyzed in urine samples from patients diagnosed with gout, type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency. Analysis of 12 biomarkers suggests damage to the kidney proximal tubule at the onset of NE. Also, upregulation of biomarkers of inflammation and leukocyte chemotaxis were detected in NE urine. Furthermore, increased clusterin levels were found in early- and late-phase NE urine. Comparative analysis revealed that clusterin is a biomarker, upregulated in NE urine.http://dx.doi.org/10.1155/2018/8658507 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ekaterina V. Martynova Adelya N. Maksudova Venera G. Shakirova Sayar R. Abdulkhakov Ilsiyar M. Khaertynova Vladimir A. Anokhin Vilena V. Ivanova Ilesanmi M. Abiola Ekaterina E. Garanina Leisan G. Tazetdinova Aigul H. Valiullina Svetlana F. Khaiboullina |
spellingShingle |
Ekaterina V. Martynova Adelya N. Maksudova Venera G. Shakirova Sayar R. Abdulkhakov Ilsiyar M. Khaertynova Vladimir A. Anokhin Vilena V. Ivanova Ilesanmi M. Abiola Ekaterina E. Garanina Leisan G. Tazetdinova Aigul H. Valiullina Svetlana F. Khaiboullina Urinary Clusterin Is Upregulated in Nephropathia Epidemica Disease Markers |
author_facet |
Ekaterina V. Martynova Adelya N. Maksudova Venera G. Shakirova Sayar R. Abdulkhakov Ilsiyar M. Khaertynova Vladimir A. Anokhin Vilena V. Ivanova Ilesanmi M. Abiola Ekaterina E. Garanina Leisan G. Tazetdinova Aigul H. Valiullina Svetlana F. Khaiboullina |
author_sort |
Ekaterina V. Martynova |
title |
Urinary Clusterin Is Upregulated in Nephropathia Epidemica |
title_short |
Urinary Clusterin Is Upregulated in Nephropathia Epidemica |
title_full |
Urinary Clusterin Is Upregulated in Nephropathia Epidemica |
title_fullStr |
Urinary Clusterin Is Upregulated in Nephropathia Epidemica |
title_full_unstemmed |
Urinary Clusterin Is Upregulated in Nephropathia Epidemica |
title_sort |
urinary clusterin is upregulated in nephropathia epidemica |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2018-01-01 |
description |
Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxicity panels 1 and 2. To determine the disease specificity, kidney damage biomarkers were also analyzed in urine samples from patients diagnosed with gout, type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency. Analysis of 12 biomarkers suggests damage to the kidney proximal tubule at the onset of NE. Also, upregulation of biomarkers of inflammation and leukocyte chemotaxis were detected in NE urine. Furthermore, increased clusterin levels were found in early- and late-phase NE urine. Comparative analysis revealed that clusterin is a biomarker, upregulated in NE urine. |
url |
http://dx.doi.org/10.1155/2018/8658507 |
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