Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside
Nowadays, research in Tissue Engineering and Regenerative Medicine is focusing on the identification of instructive scaffolds to address the requirements of both clinicians and patients to achieve prompt and adequate healing in case of injury. Among biomaterials, hemocomponents, and in particular Pl...
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doaj-69f6193cb71e4d4592b6d999555c2ff02020-11-24T21:20:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-04-01207170110.3390/ijms20071701ijms20071701Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to BedsideSilvia Barbon0Elena Stocco1Veronica Macchi2Martina Contran3Francesca Grandi4Alessio Borean5Pier Paolo Parnigotto6Andrea Porzionato7Raffaele De Caro8Department of Neuroscience, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, ItalyDepartment of Neuroscience, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, ItalyDepartment of Neuroscience, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, ItalyDepartment of Neuroscience, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, ItalyComplex Operative Unit—Pediatric Surgery, Hospital of Bolzano, Via L. Böhler 5, 39100 Bolzano, ItalyDepartment of Immunohematology and Transfusion Medicine, San Martino Hospital, 32100 Belluno, ItalyFoundation for Biology and Regenerative Medicine, Tissue Engineering and Signaling (T.E.S.) Onlus, 35131 Padua, ItalyDepartment of Neuroscience, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, ItalyDepartment of Neuroscience, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, ItalyNowadays, research in Tissue Engineering and Regenerative Medicine is focusing on the identification of instructive scaffolds to address the requirements of both clinicians and patients to achieve prompt and adequate healing in case of injury. Among biomaterials, hemocomponents, and in particular Platelet-rich Fibrin matrices, have aroused widespread interest, acting as delivery platforms for growth factors, cytokines and immune/stem-like cells for immunomodulation; their autologous origin and ready availability are also noteworthy aspects, as safety- and cost-related factors and practical aspects make it possible to shorten surgical interventions. In fact, several authors have focused on the use of Platelet-rich Fibrin in cartilage and tendon tissue engineering, reporting an increasing number of in vitro, pre-clinical and clinical studies. This narrative review attempts to compare the relevant advances in the field, with particular reference being made to the regenerative role of platelet-derived growth factors, as well as the main pre-clinical and clinical research on Platelet-rich Fibrin in chondrogenesis and tenogenesis, thereby providing a basis for critical revision of the topic.https://www.mdpi.com/1422-0067/20/7/1701platelet-rich fibrinplatelet growth factorsbiomaterialscartilage regenerationtendon regeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Silvia Barbon Elena Stocco Veronica Macchi Martina Contran Francesca Grandi Alessio Borean Pier Paolo Parnigotto Andrea Porzionato Raffaele De Caro |
spellingShingle |
Silvia Barbon Elena Stocco Veronica Macchi Martina Contran Francesca Grandi Alessio Borean Pier Paolo Parnigotto Andrea Porzionato Raffaele De Caro Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside International Journal of Molecular Sciences platelet-rich fibrin platelet growth factors biomaterials cartilage regeneration tendon regeneration |
author_facet |
Silvia Barbon Elena Stocco Veronica Macchi Martina Contran Francesca Grandi Alessio Borean Pier Paolo Parnigotto Andrea Porzionato Raffaele De Caro |
author_sort |
Silvia Barbon |
title |
Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside |
title_short |
Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside |
title_full |
Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside |
title_fullStr |
Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside |
title_full_unstemmed |
Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside |
title_sort |
platelet-rich fibrin scaffolds for cartilage and tendon regenerative medicine: from bench to bedside |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-04-01 |
description |
Nowadays, research in Tissue Engineering and Regenerative Medicine is focusing on the identification of instructive scaffolds to address the requirements of both clinicians and patients to achieve prompt and adequate healing in case of injury. Among biomaterials, hemocomponents, and in particular Platelet-rich Fibrin matrices, have aroused widespread interest, acting as delivery platforms for growth factors, cytokines and immune/stem-like cells for immunomodulation; their autologous origin and ready availability are also noteworthy aspects, as safety- and cost-related factors and practical aspects make it possible to shorten surgical interventions. In fact, several authors have focused on the use of Platelet-rich Fibrin in cartilage and tendon tissue engineering, reporting an increasing number of in vitro, pre-clinical and clinical studies. This narrative review attempts to compare the relevant advances in the field, with particular reference being made to the regenerative role of platelet-derived growth factors, as well as the main pre-clinical and clinical research on Platelet-rich Fibrin in chondrogenesis and tenogenesis, thereby providing a basis for critical revision of the topic. |
topic |
platelet-rich fibrin platelet growth factors biomaterials cartilage regeneration tendon regeneration |
url |
https://www.mdpi.com/1422-0067/20/7/1701 |
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