Flotillins in Receptor Tyrosine Kinase Signaling and Cancer
Flotillins are highly conserved proteins that localize into specific cholesterol rich microdomains in cellular membranes. They have been shown to be associated with, for example, various signaling pathways, cell adhesion, membrane trafficking and axonal growth. Recent findings have revealed that flo...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2014-02-01
|
Series: | Cells |
Subjects: | |
Online Access: | http://www.mdpi.com/2073-4409/3/1/129 |
id |
doaj-69ffc880ec2a4d21b5d9b9d8077ab3c2 |
---|---|
record_format |
Article |
spelling |
doaj-69ffc880ec2a4d21b5d9b9d8077ab3c22020-11-24T23:59:04ZengMDPI AGCells2073-44092014-02-013112914910.3390/cells3010129cells3010129Flotillins in Receptor Tyrosine Kinase Signaling and CancerAntje Banning0Nina Kurrle1Melanie Meister2Ritva Tikkanen3Institute of Biochemistry, Medical faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, GermanyInstitute of Biochemistry, Medical faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, GermanyInstitute of Biochemistry, Medical faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, GermanyInstitute of Biochemistry, Medical faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, GermanyFlotillins are highly conserved proteins that localize into specific cholesterol rich microdomains in cellular membranes. They have been shown to be associated with, for example, various signaling pathways, cell adhesion, membrane trafficking and axonal growth. Recent findings have revealed that flotillins are frequently overexpressed in various types of human cancers. We here review the suggested functions of flotillins during receptor tyrosine kinase signaling and in cancer. Although flotillins have been implicated as putative cancer therapy targets, we here show that great caution is required since flotillin ablation may result in effects that increase instead of decrease the activity of specific signaling pathways. On the other hand, as flotillin overexpression appears to be related with metastasis formation in certain cancers, we also discuss the implications of these findings for future therapy aspects.http://www.mdpi.com/2073-4409/3/1/129cancerreceptor tyrosine kinasesflotillinsmetastasismitogen activated proteins kinaseinsulindiabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antje Banning Nina Kurrle Melanie Meister Ritva Tikkanen |
spellingShingle |
Antje Banning Nina Kurrle Melanie Meister Ritva Tikkanen Flotillins in Receptor Tyrosine Kinase Signaling and Cancer Cells cancer receptor tyrosine kinases flotillins metastasis mitogen activated proteins kinase insulin diabetes |
author_facet |
Antje Banning Nina Kurrle Melanie Meister Ritva Tikkanen |
author_sort |
Antje Banning |
title |
Flotillins in Receptor Tyrosine Kinase Signaling and Cancer |
title_short |
Flotillins in Receptor Tyrosine Kinase Signaling and Cancer |
title_full |
Flotillins in Receptor Tyrosine Kinase Signaling and Cancer |
title_fullStr |
Flotillins in Receptor Tyrosine Kinase Signaling and Cancer |
title_full_unstemmed |
Flotillins in Receptor Tyrosine Kinase Signaling and Cancer |
title_sort |
flotillins in receptor tyrosine kinase signaling and cancer |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2014-02-01 |
description |
Flotillins are highly conserved proteins that localize into specific cholesterol rich microdomains in cellular membranes. They have been shown to be associated with, for example, various signaling pathways, cell adhesion, membrane trafficking and axonal growth. Recent findings have revealed that flotillins are frequently overexpressed in various types of human cancers. We here review the suggested functions of flotillins during receptor tyrosine kinase signaling and in cancer. Although flotillins have been implicated as putative cancer therapy targets, we here show that great caution is required since flotillin ablation may result in effects that increase instead of decrease the activity of specific signaling pathways. On the other hand, as flotillin overexpression appears to be related with metastasis formation in certain cancers, we also discuss the implications of these findings for future therapy aspects. |
topic |
cancer receptor tyrosine kinases flotillins metastasis mitogen activated proteins kinase insulin diabetes |
url |
http://www.mdpi.com/2073-4409/3/1/129 |
work_keys_str_mv |
AT antjebanning flotillinsinreceptortyrosinekinasesignalingandcancer AT ninakurrle flotillinsinreceptortyrosinekinasesignalingandcancer AT melaniemeister flotillinsinreceptortyrosinekinasesignalingandcancer AT ritvatikkanen flotillinsinreceptortyrosinekinasesignalingandcancer |
_version_ |
1725448259783098368 |