The diversity of immune reactions to balneotherapy and their accompaniments

• Main Authors: Zoryana Struk, Oksana Mel’nyk, Walery Zukow, Igor Popovych
• Format: Article
• Language: English
• Published: Kazimierz Wielki University 2019-11-01
• Series: Journal of Education, Health and Sport
• Subjects: immunity; microbiota; urinary syndrome; balneotherapy; truskavets’ spa.
• Online Access: https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/29022

<p class="western" style="line-height: 100%;" lang="uk-UA" align="justify"><span style="font-family: Calibri;"><span style="font-size: 12pt;"><span style="font-family: 'Times New Roman', serif;"><strong>Background.</strong></span><span style="font-family: 'Times New Roman', serif;">Earlier </span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">have been shown </span></span><span style="font-family: 'Times New Roman', serif;">that the immune responses to </span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">course of drinking of Naftussya bioactive water from Truskavet’s spa</span></span><span style="font-family: 'Times New Roman', serif;"> are ambiguous and individual. </span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en">However, at Truskavets</span></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">’</span></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en"> spa water monotherapy is a rare exception for specific contingents, whereas the vast majority of patients use a balneotherapy complex</span></span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">:</span></span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"> d</span></span></span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;">rinking of Naftus</span></span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">s</span></span></span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;">ya, application of ozokerite</span></span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"> and</span></span></span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;"> mineral baths</span></span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">.</span></span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"> The immune responses to balneotherapeutic complex are also ambiguous</span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en"> which is a separate manifestation of the multivariate effects of balneological agents as well stressors on the body. </span></span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">Therefore, the </span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"><strong>purpose</strong></span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"> of this study is to analyze variants of immune responses to balneotherapeutic complex of Truskavets’ spa. </span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"><strong>Material and methods. </strong></span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">The</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">object</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">of</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">observation</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">were</span></span><span style="font-family: 'Times New Roman', serif;"> 34</span><span style="font-family: 'Times New Roman', serif;"><span lang="en">men</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">and</span></span><span style="font-family: 'Times New Roman', serif;"> 10 </span><span style="font-family: 'Times New Roman', serif;"><span lang="en">women</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">aged</span></span><span style="font-family: 'Times New Roman', serif;">24-70</span><span style="font-family: 'Times New Roman', serif;"><span lang="en">years</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">old</span></span><span style="font-family: 'Times New Roman', serif;">,</span><span style="font-family: 'Times New Roman', serif;"><span lang="en">who</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">came</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">to</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">the</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">Truskavets</span></span><span style="font-family: 'Times New Roman', serif;">’ </span><span style="font-family: 'Times New Roman', serif;"><span lang="en">spa</span></span><span style="font-family: 'Times New Roman', serif;"> for the treatment </span><span style="font-family: 'Times New Roman', serif;"><span lang="en">of chronic pyelonephritis combined with</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">cholecystitis in</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">remission</span></span><span style="font-family: 'Times New Roman', serif;">. </span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">The survey was conducted twice, before and after balneotherapy (</span></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en">drinking Naftussya bioactive water three times a day, ozokerite applications, mineral baths every other day for 7-10 days</span></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">)</span></span></span><span style="color: #212121;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">. </span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">Immune status evaluated on a set of I and II levels recommended by the WHO. </span></span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-GB">In portion of capillary blood we counted up </span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">Leukocytogram and calculated two variants of Adaptation Index as well as two variants of Strain Index by IL Popovych. </span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-GB">We calculated also </span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">t</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-GB">he Entropy</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"> of Immunocytogram</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en"> and Leuko</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">cytogram. The condition of Microbiota is evaluated on the results of sowing of feces and urine. </span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"><strong>Results.</strong></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en"> Four variants of the immune responses to balneotherapeutic complex have been identified. In 40,9% of patients, initially normal immune status did not change significantly. In 31,8%, the lower boundary level of immunity is completely normalized. In 22,7% moderate immunosuppression is reduced, but not up to normal. However, in 4,5% of people, initially normal level of immunity are transformed into moderate immunosuppression. Discriminant analysis was conducted to identify exactly the parameters of the immunity and microbiota, in which the four immune response clusters differ significantly from each other. </span></span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">24 parameters were characteristic, </span></span><span style="font-family: 'Times New Roman', serif;">12</span><span style="font-family: 'Times New Roman', serif;"><span lang="en"> of them related to the immune parameters of the blood, one </span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">of the </span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">saliva, 5 of the feces microbiota and 3 related to urinary syndrome as well as 4 parameters are information. The o</span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en">ther </span></span><span style="font-family: 'Times New Roman', serif;">25</span><span style="font-family: 'Times New Roman', serif;"><span lang="en"> parameters were outside the discriminatory mode</span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en">l</span></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">. </span></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US"><strong>Conclusion.</strong></span></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en"> The immunotropic effect of balneotherapy on certain individuals is not effective enough, and in some cases </span></span></span><span style="color: #222222;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-US">even</span></span></span><span style="font-family: 'Times New Roman', serif;"><span lang="en"> unfavorable.</span></span></span></span></p>