Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

Cell fate determination during development often requires morphogen transport from producing to distant responding cells. Hedgehog (Hh) morphogens present a challenge to this concept, as all Hhs are synthesized as terminally lipidated molecules that form insoluble clusters at the surface of producin...

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Bibliographic Details
Main Authors: Sabine Schürmann, Georg Steffes, Dominique Manikowski, Philipp Kastl, Ursula Malkus, Shyam Bandari, Stefanie Ohlig, Corinna Ortmann, Rocio Rebollido-Rios, Mandy Otto, Harald Nüsse, Daniel Hoffmann, Christian Klämbt, Milos Galic, Jürgen Klingauf, Kay Grobe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
hedgehog
morphogen
patterning
wing
proteolysis
Online Access:https://elifesciences.org/articles/33033

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