Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
Abstract Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study...
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2017-08-01
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doaj-6a10b13ce9a7434fb370ce14a233ebf82020-12-08T00:05:01ZengNature Publishing GroupScientific Reports2045-23222017-08-017111010.1038/s41598-017-07681-zLateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity DisorderFrancisco Zamorano0Pablo Billeke1Leonie Kausel2Josefina Larrain3Ximena Stecher4Jose M. Hurtado5Vladimir López6Ximena Carrasco7Francisco Aboitiz8División de Neurociencia, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del DesarrolloDivisión de Neurociencia, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del DesarrolloCentro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de ChileDivisión de Neurociencia, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del DesarrolloUnidad de Imágenes Cuantitativas Avanzadas, Departamento de Imágenes, Clínica Alemana de SantiagoDivisión de Neurociencia, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del DesarrolloCentro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de ChileServicio de Neurología, Facultad de Medicina, Clínica Alemana Universidad del DesarrolloCentro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de ChileAbstract Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a “congruent condition” and an “incongruent condition”. The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -a greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT.https://doi.org/10.1038/s41598-017-07681-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francisco Zamorano Pablo Billeke Leonie Kausel Josefina Larrain Ximena Stecher Jose M. Hurtado Vladimir López Ximena Carrasco Francisco Aboitiz |
spellingShingle |
Francisco Zamorano Pablo Billeke Leonie Kausel Josefina Larrain Ximena Stecher Jose M. Hurtado Vladimir López Ximena Carrasco Francisco Aboitiz Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder Scientific Reports |
author_facet |
Francisco Zamorano Pablo Billeke Leonie Kausel Josefina Larrain Ximena Stecher Jose M. Hurtado Vladimir López Ximena Carrasco Francisco Aboitiz |
author_sort |
Francisco Zamorano |
title |
Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder |
title_short |
Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder |
title_full |
Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder |
title_fullStr |
Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder |
title_full_unstemmed |
Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder |
title_sort |
lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in attention deficit hyperactivity disorder |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-08-01 |
description |
Abstract Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a “congruent condition” and an “incongruent condition”. The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -a greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT. |
url |
https://doi.org/10.1038/s41598-017-07681-z |
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