Spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation
Characterization of the electrical activity of the retina in the animal models of retinal degeneration has been carried out in part to understand the progression of retinal degenerative diseases like age-related macular degeneration (AMD) and retinitis pigmentosa (RP), but also to determine optimum...
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doaj-6a140b9900d249659b6d5e26858f49772020-11-24T22:51:21ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022016-01-01910.3389/fncel.2015.00512168764Spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulationYong Sook eGoo0Yong Sook eGoo1Dae Jin ePark2Dae Jin ePark3Jung Ryul eAhn4Jung Ryul eAhn5Solomon S Senok6Chungbuk National University School of MedicineNano Artificial Vision Research Center, Seoul National University HospitalChungbuk National University School of MedicineNano Artificial Vision Research Center, Seoul National University HospitalChungbuk National University School of MedicineNano Artificial Vision Research Center, Seoul National University HospitalNeuroscience Division, Alfaisal University College of MedicineCharacterization of the electrical activity of the retina in the animal models of retinal degeneration has been carried out in part to understand the progression of retinal degenerative diseases like age-related macular degeneration (AMD) and retinitis pigmentosa (RP), but also to determine optimum stimulus paradigms for use with retinal prosthetic devices. The models most studied in this regard have been the two lines of mice deficient in the β-subunit of phosphodiesterase (rd1 and rd10 mice), where the degenerating retinas exhibit characteristic spontaneous hyperactivity and oscillatory local field potentials (LFPs). Additionally, there is a robust ~10 Hz rhythmic burst of retinal ganglion cell (RGC) spikes on the trough of the oscillatory LFP. In rd1 mice, the rhythmic burst of RGC spikes is always phase-locked with the oscillatory LFP and this phase-locking property is preserved regardless of postnatal ages. However, in rd10 mice, the frequency of the oscillatory rhythm changes according to postnatal age, suggesting that this rhythm might be a marker of the stage of degeneration. Furthermore when a biphasic current stimulus is applied to rd10 mice degenerate retina, distinct RGC response patterns that correlate with the stage of degeneration emerge. This review also considers the significance of these response properties.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00512/fullRetinal Degenerationretinal ganglion cellrd1 micerd10 miceoscillatory local field potential |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Sook eGoo Yong Sook eGoo Dae Jin ePark Dae Jin ePark Jung Ryul eAhn Jung Ryul eAhn Solomon S Senok |
spellingShingle |
Yong Sook eGoo Yong Sook eGoo Dae Jin ePark Dae Jin ePark Jung Ryul eAhn Jung Ryul eAhn Solomon S Senok Spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation Frontiers in Cellular Neuroscience Retinal Degeneration retinal ganglion cell rd1 mice rd10 mice oscillatory local field potential |
author_facet |
Yong Sook eGoo Yong Sook eGoo Dae Jin ePark Dae Jin ePark Jung Ryul eAhn Jung Ryul eAhn Solomon S Senok |
author_sort |
Yong Sook eGoo |
title |
Spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation |
title_short |
Spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation |
title_full |
Spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation |
title_fullStr |
Spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation |
title_full_unstemmed |
Spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation |
title_sort |
spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2016-01-01 |
description |
Characterization of the electrical activity of the retina in the animal models of retinal degeneration has been carried out in part to understand the progression of retinal degenerative diseases like age-related macular degeneration (AMD) and retinitis pigmentosa (RP), but also to determine optimum stimulus paradigms for use with retinal prosthetic devices. The models most studied in this regard have been the two lines of mice deficient in the β-subunit of phosphodiesterase (rd1 and rd10 mice), where the degenerating retinas exhibit characteristic spontaneous hyperactivity and oscillatory local field potentials (LFPs). Additionally, there is a robust ~10 Hz rhythmic burst of retinal ganglion cell (RGC) spikes on the trough of the oscillatory LFP. In rd1 mice, the rhythmic burst of RGC spikes is always phase-locked with the oscillatory LFP and this phase-locking property is preserved regardless of postnatal ages. However, in rd10 mice, the frequency of the oscillatory rhythm changes according to postnatal age, suggesting that this rhythm might be a marker of the stage of degeneration. Furthermore when a biphasic current stimulus is applied to rd10 mice degenerate retina, distinct RGC response patterns that correlate with the stage of degeneration emerge. This review also considers the significance of these response properties. |
topic |
Retinal Degeneration retinal ganglion cell rd1 mice rd10 mice oscillatory local field potential |
url |
http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00512/full |
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