P7.12 PULSE PRESSURE AND INTIMA MEDIA THICKNESS IN RELATION TO SERUM VITAMIN D CONCENTRATION IN A SAMPLE OF GENERAL POPULATION

• Main Authors: Agata Franczyk*, Katarzyna Stolarz-Skrzypek, Agnieszka Olszanecka, Wiktoria Wojciechowska, Anna Wesoαowska, Kalina Kawecka-Jaszcz, Danuta Czarnecka
• Format: Article
• Language: English
• Published: Atlantis Press 2015-11-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125930679/view

Objectives: Vitamin D regulates the renin-angiotensin-aldosterone system, inhibits proliferation of cardiomyocytes and vascular smooth muscles and has anti-inflammatory effects. We aimed to investigate the relation between serum vitamin D concentration and arterial structure and function in a sample of general population. Methods: The study group included 303 subjects recruited from general population. Office BP was measured at 2 separate visits, 5 times at each visit. SpaceLabs90207 oscillometric monitors were programmed to measure ambulatory BP (ABP) each 15 min. daytime (6.00 – 22.00) and each 30 min. nighttime. Ultrasound examination of carotid arteries allowed to obtain the intima media thickness(IMT). Based on the ABP data, we calculated pulse pressure (PP) over 24h, daytime and nighttime. Vitamin D concentration was measured in serum. Database management and multivariate analyses were performed with SAS software (SAS Institute, Cary, NC, version9.3). Results: The study group included 138 men and 165 women, mean age = 47 ± 16 years, 164 subjects had hypertension. Mean serum vitamin D level was 21.1±8.7 ng/ml. With adjustments applied for age, sex, body mass index, 24-hour systolic blood pressure and smoking, serum vitamin D negatively correlated with 24h PP (beta=−0,05±0,038, p=0,05) and daytime PP (beta=−0,035±0,027, p=0,05). We observed positive correlation between IMT and vitamin D in two subgroups: in younger population (mean age=34,8yrs, beta=0,01±0,019, p=0,03) and in male participants(beta=0,0012±0,052, p=0,03). Conclusion: In that general population, vitamin D concentration was negatively associated with 24 h and daytime pulse pressure. Higher cholecalciferol was related to intima media thickness but only in men and in young individuals.