B Cell Competition for Restricted T Cell Help Suppresses Rare-Epitope Responses

Summary: The immune system responds preferentially to particular antigenic-epitopes contained within complex immunogens, such as proteins or microbes. This poorly understood phenomenon, termed “immunodominance,” remains an obstacle to achieving polyvalent immune responses against multiple antigenic-...

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Bibliographic Details
Main Authors: Matthew Charles Woodruff, Eui Ho Kim, Wei Luo, Bali Pulendran
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718314591

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