Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives

Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives

The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O...

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Main Authors: S. P. Vartale, N. K. Halikar, Y. D. Pawar
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/862651
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spelling doaj-6a2269c133c5480da6637ce1cb9d3ac32020-11-24T21:59:59ZengHindawi LimitedJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/862651862651Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted DerivativesS. P. Vartale0N. K. Halikar1Y. D. Pawar2Department of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaDepartment of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaDepartment of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaThe 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O-, and C-nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group.http://dx.doi.org/10.1155/2013/862651
collection DOAJ
language English
format Article
sources DOAJ
author S. P. Vartale
N. K. Halikar
Y. D. Pawar
spellingShingle S. P. Vartale
N. K. Halikar
Y. D. Pawar
Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
Journal of Chemistry
author_facet S. P. Vartale
N. K. Halikar
Y. D. Pawar
author_sort S. P. Vartale
title Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
title_short Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
title_full Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
title_fullStr Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
title_full_unstemmed Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
title_sort synthesis and antimicrobial activity of 3-cyano-4-imino-9-methoxy-4h-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-substituted derivatives
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2013-01-01
description The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O-, and C-nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group.
url http://dx.doi.org/10.1155/2013/862651
work_keys_str_mv AT spvartale synthesisandantimicrobialactivityof3cyano4imino9methoxy4hpyrimido21bpyrimido45bquinolineand2substitutedderivatives
AT nkhalikar synthesisandantimicrobialactivityof3cyano4imino9methoxy4hpyrimido21bpyrimido45bquinolineand2substitutedderivatives
AT ydpawar synthesisandantimicrobialactivityof3cyano4imino9methoxy4hpyrimido21bpyrimido45bquinolineand2substitutedderivatives
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