Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O...
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doaj-6a2269c133c5480da6637ce1cb9d3ac32020-11-24T21:59:59ZengHindawi LimitedJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/862651862651Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted DerivativesS. P. Vartale0N. K. Halikar1Y. D. Pawar2Department of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaDepartment of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaDepartment of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaThe 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O-, and C-nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group.http://dx.doi.org/10.1155/2013/862651 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. P. Vartale N. K. Halikar Y. D. Pawar |
spellingShingle |
S. P. Vartale N. K. Halikar Y. D. Pawar Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives Journal of Chemistry |
author_facet |
S. P. Vartale N. K. Halikar Y. D. Pawar |
author_sort |
S. P. Vartale |
title |
Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
title_short |
Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
title_full |
Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
title_fullStr |
Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
title_full_unstemmed |
Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
title_sort |
synthesis and antimicrobial activity of 3-cyano-4-imino-9-methoxy-4h-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-substituted derivatives |
publisher |
Hindawi Limited |
series |
Journal of Chemistry |
issn |
2090-9063 2090-9071 |
publishDate |
2013-01-01 |
description |
The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O-, and C-nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group. |
url |
http://dx.doi.org/10.1155/2013/862651 |
work_keys_str_mv |
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