Role of multidomain structure of urokinase in regulation of growth and remodeling of vessels

• Main Authors: V. A. Tkachuk, O. S. Plekhanova, I. B. Beloglazova, E. V. Parfenova
• Format: Article
• Language: English
• Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2013-12-01
• Series: Ukrainian Biochemical Journal
• Subjects: angiogenesis; migration; prolife­ration; remodeling of arteries; urokinase
• Online Access: http://ukrbiochemjournal.org/wp-content/uploads/2015/11/Tkachuk_6_13.pdf

Urokinase type plasminogen activator, or urokinase (uPA), is a multifunctional protein which plays special regulatory role in the vascular wall and can actuate the proteolytic and signal cascades. The authors’ results and literature data concerning the role of urokinase in remodeling blood vessels and angiogenesis are summarized in the paper. At the present stage urokinase may be conside­red as a promising target for the effects directed to prophylaxis of restenoses, to preventing of negative remodeling of arteries­, stimulation of vessels growth under the ischemic diseases and suppression of angiogenesis under oncologic diseases