A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case Studies
Purpose: Clinical myocardial perfusion SPECT is commonly performed using static imaging. Dynamic SPECT enables extraction of quantitative as well as relative perfusion information. We aimed to evaluate the ability of dynamic SPECT for regular perfusion assessment in comparison to conventional SPECT...
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doaj-6a27141395d140b79808ee9866c952ff2020-11-25T04:07:01ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372014-06-0112A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case StudiesZohreh Shahpouri0Alireza Kamali-Asl1Ahmad Bitarafan-Rajabi2Jakir Hossain3Seyed Mohammad Entezarmahdi4Samane Mohseni5Nahid Yaghoobi6Arman Rahmim7Radiation Medicine Engineering Dept. Shahid Beheshti University, GC, Iran.Radiation Medicine Engineering Dept. Shahid Beheshti University, GC, Iran.Cardiovascular Interventional Research Center; Department of Nuclear Medicine, Rajaei Cardiovascular, Medical & Research Center, Iran University of medical sciences, Iran.Departments of Radiology & Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, USA.Radiation Medicine Engineering Dept. Shahid Beheshti University, GC, IranRadiation Medicine Engineering Dept. Shahid Beheshti University, GC, IranDepartment of Nuclear Medicine, Rajaei Cardiovascular, Medical & Research Center, Iran University of Medical Sciences, Iran.Departments of Radiology & Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, USA AND Departments of Electrical & Computer Engineering, Johns Hopkins University, School of Medicine, Baltimore, USA. Purpose: Clinical myocardial perfusion SPECT is commonly performed using static imaging. Dynamic SPECT enables extraction of quantitative as well as relative perfusion information. We aimed to evaluate the ability of dynamic SPECT for regular perfusion assessment in comparison to conventional SPECT in the context of thallium-201. Methods: Simulations were performed utilizing a 4D-NCAT phantom for a dual-head gamma camera via the SIMIND Monte-Carlo simulator. 64s acquisition time-frames were used to track these dynamic changes. Different summations of time-frames were performed to create each dataset, which were compared to a standard static dataset. In addition, the effect of different delay-times post-injection was assessed. Twenty-segment analysis of perfusion was performed via the QPS analyser. Dynamic data were subsequently acquired in clinical studies using simulation-optimized protocols. Results: For different summations of time-frames, perfusion scores in the basal and mid regions revealed 14.4% and 7.3% increases in dynamic SPECT compared to conventional imaging, with maximum changes in the basal anterior, while the distal and apical segments did not show noticeable changes. Specifically, dynamic imaging including 4 to 6 time-frames yielded enhanced correlation (R=0.957) with conventional imaging, in comparision to the usage of less time frames. Greatest correlation with conventional imaging was obtained for post-injection delays of 320 to 448s (R=0.982 to R=0.988). Conclusion: While dynamic SPECT opens up an important opportunity for quantitative assessment (e.g. via generation of kinetic parameters), it was shown to generate highly consistent perfusion information compared to established conventional imaging. Future work focuses on merging these two important capabilities. https://fbt.tums.ac.ir/index.php/fbt/article/view/27Dynamic SPECTCardiac Perfusion ImagingThallium. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zohreh Shahpouri Alireza Kamali-Asl Ahmad Bitarafan-Rajabi Jakir Hossain Seyed Mohammad Entezarmahdi Samane Mohseni Nahid Yaghoobi Arman Rahmim |
spellingShingle |
Zohreh Shahpouri Alireza Kamali-Asl Ahmad Bitarafan-Rajabi Jakir Hossain Seyed Mohammad Entezarmahdi Samane Mohseni Nahid Yaghoobi Arman Rahmim A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case Studies Frontiers in Biomedical Technologies Dynamic SPECT Cardiac Perfusion Imaging Thallium. |
author_facet |
Zohreh Shahpouri Alireza Kamali-Asl Ahmad Bitarafan-Rajabi Jakir Hossain Seyed Mohammad Entezarmahdi Samane Mohseni Nahid Yaghoobi Arman Rahmim |
author_sort |
Zohreh Shahpouri |
title |
A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case Studies |
title_short |
A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case Studies |
title_full |
A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case Studies |
title_fullStr |
A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case Studies |
title_full_unstemmed |
A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case Studies |
title_sort |
comparative assessment of dynamic and conventional thallium-201 spect myocardial perfusion imaging: monte carlo simulations and case studies |
publisher |
Tehran University of Medical Sciences |
series |
Frontiers in Biomedical Technologies |
issn |
2345-5837 |
publishDate |
2014-06-01 |
description |
Purpose: Clinical myocardial perfusion SPECT is commonly performed using static imaging. Dynamic SPECT enables extraction of quantitative as well as relative perfusion information. We aimed to evaluate the ability of dynamic SPECT for regular perfusion assessment in comparison to conventional SPECT in the context of thallium-201.
Methods: Simulations were performed utilizing a 4D-NCAT phantom for a dual-head gamma camera via the SIMIND Monte-Carlo simulator. 64s acquisition time-frames were used to track these dynamic changes. Different summations of time-frames were performed to create each dataset, which were compared to a standard static dataset. In addition, the effect of different delay-times post-injection was assessed. Twenty-segment analysis of perfusion was performed via the QPS analyser. Dynamic data were subsequently acquired in clinical studies using simulation-optimized protocols.
Results: For different summations of time-frames, perfusion scores in the basal and mid regions revealed 14.4% and 7.3% increases in dynamic SPECT compared to conventional imaging, with maximum changes in the basal anterior, while the distal and apical segments did not show noticeable changes. Specifically, dynamic imaging including 4 to 6 time-frames yielded enhanced correlation (R=0.957) with conventional imaging, in comparision to the usage of less time frames. Greatest correlation with conventional imaging was obtained for post-injection delays of 320 to 448s (R=0.982 to R=0.988).
Conclusion: While dynamic SPECT opens up an important opportunity for quantitative assessment (e.g. via generation of kinetic parameters), it was shown to generate highly consistent perfusion information compared to established conventional imaging. Future work focuses on merging these two important capabilities.
|
topic |
Dynamic SPECT Cardiac Perfusion Imaging Thallium. |
url |
https://fbt.tums.ac.ir/index.php/fbt/article/view/27 |
work_keys_str_mv |
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