The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma
Background: Myomas are benign monoclonal tumors of the smooth muscle cells of the endometrium. Venous thromboembolism (VTE) is a common complication of cancers; however, their contributions to thrombotic tendency in patients with cancer have conflicting results. The present study was designed to inv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Vesnu Publications
2014-11-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3979 |
| Summary: | Background: Myomas are benign monoclonal tumors of the smooth muscle cells of the endometrium. Venous thromboembolism (VTE) is a common complication of cancers; however, their contributions to thrombotic tendency in patients with cancer have conflicting results. The present study was designed to investigate the relationship of the polymorphisms of clotting factor gene and the risk of uterine myoma.
Methods: In this study, three selected polymorphisms of thrombotic factors gene were evaluated using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method. We focused on the prevalence of PTH G20210A, FGB G-455A and PAI-1 4G/5G polymorphisms in 50 women with clinically diagnosed uterine myoma and 50 healthy controls. The data were analyzed using chi-square test via SPSS19 software.
Findings: The PTH (rs1799963), FGB (rs1800790) and PAI-1 (rs1799889) polymorphisms were not correlated with an increased risk of uterine myoma in the study population (P > 0.05).
Conclusion: We observed no associations of the investigated polymorphisms with the risk of uterine myoma in studied population. |
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| ISSN: | 1027-7595 1735-854X |