Oxidative Stress and Its Correction in Patients with Severe Concomitant Injury

In severe concomitant injury, there is evidently activated formation of free radicals with a further increase in the rate of lipid per-oxidation and with simultaneous depletion of antioxidant system activity. The administration of the traditional doses of antioxi-dants is ineffective. Higher-dose an...

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Bibliographic Details
Main Authors: V. M. Kapitonov, D. A. Ostapchenko
Format: Article
Language:Russian
Published: Russian Academy of Medical Sciences 2010-08-01
Series:Obŝaâ Reanimatologiâ
Online Access:https://www.reanimatology.com/rmt/article/view/419
Description
Summary:In severe concomitant injury, there is evidently activated formation of free radicals with a further increase in the rate of lipid per-oxidation and with simultaneous depletion of antioxidant system activity. The administration of the traditional doses of antioxi-dants is ineffective. Higher-dose antioxidant therapy and use of novel agents can cause a considerable reduction in the rate of free radical processes and improve the results of treatment. Key words: oxidative stress, lipid peroxidation, antioxidants, lactoferrin.
ISSN:1813-9779
2411-7110