Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2

Insulin secretion from β-cells is reduced at the onset of type-1 and during type-2 diabetes. Although inflammation and metabolic dysfunction of β-cells elicit secretory defects associated with type-1 or type-2 diabetes, accompanying changes to insulin granules have not been established. To address t...

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Bibliographic Details
Main Authors: Alex J B Kreutzberger, Volker Kiessling, Catherine A Doyle, Noah Schenk, Clint M Upchurch, Margaret Elmer-Dixon, Amanda E Ward, Julia Preobraschenski, Syed S Hussein, Weronika Tomaka, Patrick Seelheim, Iman Kattan, Megan Harris, Binyong Liang, Anne K Kenworthy, Bimal N Desai, Norbert Leitinger, Arun Anantharam, J David Castle, Lukas K Tamm
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
insulin
secretion
exocytosis
diabetes
fusion
synaptotagmin
Online Access:https://elifesciences.org/articles/62506

Internet

https://elifesciences.org/articles/62506

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