Tumour‐derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour‐bearing mice

Tumour‐derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour‐bearing mice

Abstract Background Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted by C26 colon carcinoma cells was respons...

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Bibliographic Details
Main Authors: Susan C. Kandarian, Rachel L. Nosacka, Andrea E. Delitto, Andrew R. Judge, Sarah M. Judge, John D. Ganey, Jesse D. Moreira, Robert W. Jackman
Format: Article
Language:English
Published: Wiley 2018-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Skeletal muscle
Atrophy
Wasting
CRISPR
Tumour
Cachexia
Online Access:https://doi.org/10.1002/jcsm.12346

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