Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes Mellitus
Introduction: Neutrophil-Lymphocyte Ratio (NLR) is an easily measurable novel marker of systemic inflammation and is related to cardiovascular disease in patients with type 2 diabetes mellitus. Glycated haemoglobin A (HbA1c) levels are an indicator of blood glucose regulation. However, HbA1c us...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Pvt. Ltd.
2021-07-01
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Series: | National Journal of Laboratory Medicine |
Subjects: | |
Online Access: | http://www.njlm.net/articles/PDF/2518/48542_CE[Ra1]_F(SHU)_PF1(JY_SHU)_PFA(JY_KM)_PN(KM).pdf |
Summary: | Introduction: Neutrophil-Lymphocyte Ratio (NLR) is an easily
measurable novel marker of systemic inflammation and
is related to cardiovascular disease in patients with type 2
diabetes mellitus. Glycated haemoglobin A (HbA1c) levels
are an indicator of blood glucose regulation. However, HbA1c
usually do not predict diabetes associated complications
accurately.
Aim: To measure NLR and HbA1c values and to determine their
association in patients with type 2 diabetes mellitus.
Materials and Methods: This observational analytical study
was conducted in a tertiary care center. Data was collected
over a period of six months from June 2020 to December 2020.
Hundred random patients diagnosed with type 2 diabetes
mellitus according to American Diabetes Association (ADA)
criteria were included in the study. Patients were divided into
two groups, Group A with HbA1c ≤7 (regulated diabetes) &
Group B with >7 HbA1c (unregulated diabetes).
Results: Using Independent t-test, the NLR ratios were
found to be significantly higher in Group B when compared
to Group A (2.41±0.11 verses 1.31±0.57, respectively). Mean
HbA1c (%) levels were 6.67±0.14 and 8.79±0.21 in Groups A
and B, respectively. Linear regression analysis showed that NLR
correlated positively with HbA1c with a p-value <0.001.
Conclusion: NLR is an easily available, safe, cost-effective and
simple test. It can also guide the physician in resource limited
settings like Primary Health Centres (PHC) to evaluate a patient
with type 2 diabetes for microvascular and macrovascular
complications. So, it can be used as a disease monitoring tool
during the follow up of diabetics. |
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ISSN: | 2277-8551 2455-6882 |