Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes Mellitus
Introduction: Neutrophil-Lymphocyte Ratio (NLR) is an easily measurable novel marker of systemic inflammation and is related to cardiovascular disease in patients with type 2 diabetes mellitus. Glycated haemoglobin A (HbA1c) levels are an indicator of blood glucose regulation. However, HbA1c us...
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doaj-6a35ca97530743bba90cc01aea05f7432021-07-13T06:47:50ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822021-07-01103PO70PO7210.7860/NJLM/2021/48542:2518Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes MellitusPranathi Mahankali0Sruthi Nannapaneni1kalyan chakravarthy Vallabhaneni2Naveen chandra rao Damera3Rangarao Diddi4Postgraduate, Department of Pathology, Dr Psims&rf, Vijayawada, Andhra Pradesh, India.Assistant Professor, Department of Pathology, Dr Psims&rf, Vijayawada, Andhra Pradesh, India.Professor, Department of Pathology, Dr Psims&rf, Vijayawada, Andhra Pradesh, India.Professor, Department of Pathology, Dr Psims&rf, Vijayawada, Andhra Pradesh, India.Professor and Head, Department of Pathology, Dr Psims&rf, Vijayawada, Andhra Pradesh, India.Introduction: Neutrophil-Lymphocyte Ratio (NLR) is an easily measurable novel marker of systemic inflammation and is related to cardiovascular disease in patients with type 2 diabetes mellitus. Glycated haemoglobin A (HbA1c) levels are an indicator of blood glucose regulation. However, HbA1c usually do not predict diabetes associated complications accurately. Aim: To measure NLR and HbA1c values and to determine their association in patients with type 2 diabetes mellitus. Materials and Methods: This observational analytical study was conducted in a tertiary care center. Data was collected over a period of six months from June 2020 to December 2020. Hundred random patients diagnosed with type 2 diabetes mellitus according to American Diabetes Association (ADA) criteria were included in the study. Patients were divided into two groups, Group A with HbA1c ≤7 (regulated diabetes) & Group B with >7 HbA1c (unregulated diabetes). Results: Using Independent t-test, the NLR ratios were found to be significantly higher in Group B when compared to Group A (2.41±0.11 verses 1.31±0.57, respectively). Mean HbA1c (%) levels were 6.67±0.14 and 8.79±0.21 in Groups A and B, respectively. Linear regression analysis showed that NLR correlated positively with HbA1c with a p-value <0.001. Conclusion: NLR is an easily available, safe, cost-effective and simple test. It can also guide the physician in resource limited settings like Primary Health Centres (PHC) to evaluate a patient with type 2 diabetes for microvascular and macrovascular complications. So, it can be used as a disease monitoring tool during the follow up of diabetics.http://www.njlm.net/articles/PDF/2518/48542_CE[Ra1]_F(SHU)_PF1(JY_SHU)_PFA(JY_KM)_PN(KM).pdfglycated haemoglobin amicrovascularmacrovascularunregulated diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pranathi Mahankali Sruthi Nannapaneni kalyan chakravarthy Vallabhaneni Naveen chandra rao Damera Rangarao Diddi |
spellingShingle |
Pranathi Mahankali Sruthi Nannapaneni kalyan chakravarthy Vallabhaneni Naveen chandra rao Damera Rangarao Diddi Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes Mellitus National Journal of Laboratory Medicine glycated haemoglobin a microvascular macrovascular unregulated diabetes |
author_facet |
Pranathi Mahankali Sruthi Nannapaneni kalyan chakravarthy Vallabhaneni Naveen chandra rao Damera Rangarao Diddi |
author_sort |
Pranathi Mahankali |
title |
Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes Mellitus |
title_short |
Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes Mellitus |
title_full |
Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes Mellitus |
title_fullStr |
Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes Mellitus |
title_full_unstemmed |
Association of Neutrophil Lymphocyte Ratio and Glycaemic Control in Patients with Type 2 Diabetes Mellitus |
title_sort |
association of neutrophil lymphocyte ratio and glycaemic control in patients with type 2 diabetes mellitus |
publisher |
JCDR Research and Publications Pvt. Ltd. |
series |
National Journal of Laboratory Medicine |
issn |
2277-8551 2455-6882 |
publishDate |
2021-07-01 |
description |
Introduction: Neutrophil-Lymphocyte Ratio (NLR) is an easily
measurable novel marker of systemic inflammation and
is related to cardiovascular disease in patients with type 2
diabetes mellitus. Glycated haemoglobin A (HbA1c) levels
are an indicator of blood glucose regulation. However, HbA1c
usually do not predict diabetes associated complications
accurately.
Aim: To measure NLR and HbA1c values and to determine their
association in patients with type 2 diabetes mellitus.
Materials and Methods: This observational analytical study
was conducted in a tertiary care center. Data was collected
over a period of six months from June 2020 to December 2020.
Hundred random patients diagnosed with type 2 diabetes
mellitus according to American Diabetes Association (ADA)
criteria were included in the study. Patients were divided into
two groups, Group A with HbA1c ≤7 (regulated diabetes) &
Group B with >7 HbA1c (unregulated diabetes).
Results: Using Independent t-test, the NLR ratios were
found to be significantly higher in Group B when compared
to Group A (2.41±0.11 verses 1.31±0.57, respectively). Mean
HbA1c (%) levels were 6.67±0.14 and 8.79±0.21 in Groups A
and B, respectively. Linear regression analysis showed that NLR
correlated positively with HbA1c with a p-value <0.001.
Conclusion: NLR is an easily available, safe, cost-effective and
simple test. It can also guide the physician in resource limited
settings like Primary Health Centres (PHC) to evaluate a patient
with type 2 diabetes for microvascular and macrovascular
complications. So, it can be used as a disease monitoring tool
during the follow up of diabetics. |
topic |
glycated haemoglobin a microvascular macrovascular unregulated diabetes |
url |
http://www.njlm.net/articles/PDF/2518/48542_CE[Ra1]_F(SHU)_PF1(JY_SHU)_PFA(JY_KM)_PN(KM).pdf |
work_keys_str_mv |
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